MAGNETIC RESONANCE IMAGING WITH DIFFUSE WEIGHTED IMAGING AND COMPUTED TOMOGRAPHY WITH INTRAVENOUS CONTRAST IN STAGING OF DISSEMINATED OVARIAN, STOMACH, COLORECTAL CANCER

  • Sergiy Chetverikov Center of Reconstructive and Restorative Medicine University Clinic of Odessa National Medical University, Ukraine
  • Svitlana Zavoloka Center of Reconstructive and Restorative Medicine University Clinic of Odessa National Medical University, Ukraine
  • Viacheslav Onyshchenko Odessa National Medical University, Ukraine
  • Mykhailo Chetverikov Center of Reconstructive and Restorative Medicine University Clinic of Odessa National Medical University, Ukraine
  • Valeriia Chetverikova-Ovchynnyk Center of Reconstructive and Restorative Medicine University Clinic of Odessa National Medical University, Ukraine
Keywords: magnetic resonance imaging with diffuse-weighted imaging (DWI / MRI), computed tomography (CT), peritoneal carcinoma index (PCI), cytoreductive surgery

Abstract

The aim of the research. Development and implementation of new methods for pre-operative staging of advanced ovarian, gastric and colorectal cancer to improve patient selection for cytoreductive surgery and increase its radicality.

Materials and methods. Data from 120 patients with advanced ovarian cancer, 28 with advanced gastric cancer and 119 with advanced colorectal cancer were analyzed. Preoperative detection of the incidence of peritoneal carcinoma and the possibility of surgery in radical or cytoreductive volume performed by CT with intravenous contrast (72 patients with ovarian cancer, 17 patients with gastric cancer, and 69 patients with colorectal cancer), and MR T1 and T2, contrast-enhanced T1, and diffuse-weighted sequences (48 patients with ovarian cancer, 11 patients with gastric cancer, and 50 patients with colorectal cancer). Subsequently, preoperative and intraoperative assessment of the prevalence of the tumour process with peritoneal carcinoma index (PCI) by Sugarbaker was performed.

Results. A statistically significant increase in the informativeness of the preoperative assessment of the incidence of tumour process in peritoneum and the presence of distant metastases using DWI / MRI compared with CT with intravenous contrast was determined. Patients from all groups were categorized according to the completeness index of cytoreduction achieved by preoperative staging and patient selection using DWI / MRI and CT. The use of DWI / MRI allowed to significantly reduce the number of suboptimal and non-optimal cytoreductive interventions.

Conclusions. DWI / MRI has made it possible to significantly improve the preoperative incidence of advanced ovarian, gastric, and colorectal cancer compared to CT, predict the radicality of future surgery, and detect inoperable cases.

Downloads

Download data is not yet available.

Author Biographies

Sergiy Chetverikov, Center of Reconstructive and Restorative Medicine University Clinic of Odessa National Medical University

Surgery department No.4 with oncology course

Svitlana Zavoloka, Center of Reconstructive and Restorative Medicine University Clinic of Odessa National Medical University

Surgery department No. 4 with oncology course

Viacheslav Onyshchenko, Odessa National Medical University

Department of simulation medicine

References

Hallam, S., Tyler, R., Price, M., Beggs, A., Youssef, H. (2019). Meta‐analysis of prognostic factors for patients with colorectal peritoneal metastasis undergoing cytoreductive surgery and heated intraperitoneal chemotherapy. BJS Open, 3 (5), 585–594. doi: http://doi.org/10.1002/bjs5.50179

Wang, H. M., Wang, G. Y., Huang, Y., Ren, L., Zhang, H., Wu, A. W. et. al. (2019). The status analysis of diagnosis and treatment of synchronous peritoneal carcinomatosis from colorectal cancer in China: a report of 1 003 cases in 16 domestic medical centers. Zhonghua Wai Ke Za Zhi, 57 (9), 666–672.

Thomassin-Naggara, I., Darai, E., Lécuru, F., Fournier, L. (2019). Diagnostic value of imaging (ultrasonography, doppler, CT, MR, PET-CT) for the diagnosis of a suspicious ovarian mass and staging of ovarian, tubal or primary peritoneal cancer: Article drafted from the French Guidelines in oncology entitled "Initial management of patients with epithelial ovarian cancer" developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY under the aegis of CNGOF and endorsed by INCa. Gynécologie Obstétrique Fertilité & Sénologie, 47 (2), 123–133. doi: http://doi.org/10.1016/j.gofs.2018.12.012

Elzarkaa, A. A., Shaalan, W., Elemam, D., Mansour, H., Melis, M., Malik, E., Soliman, A. A. (2018). Peritoneal cancer index as a predictor of survival in advanced stage serous epithelial ovarian cancer: a prospective study. Journal of Gynecologic Oncology, 29 (4). doi: http://doi.org/10.3802/jgo.2018.29.e47

Huang, Y., Alzahrani, N. A., Chua, T. C., Liauw, W., Morris, D. L. (2016). Impacts of peritoneal cancer index on the survival outcomes of patients with colorectal peritoneal carcinomatosis. International Journal of Surgery, 32, 65–70. doi: http://doi.org/10.1016/j.ijsu.2016.06.033

Van ’t Sant, I., van Eden, W. J., Engbersen, M. P., Kok, N. F. M., Woensdregt, K., Lambregts, D. M. J. et. al. (2018). Diffusion-weighted MRI assessment of the peritoneal cancer index before cytoreductive surgery. British Journal of Surgery, 106 (4), 491–498. doi: http://doi.org/10.1002/bjs.10989

Cianci, R., Pizzi, A. D., Patriarca, G., Massari, R., Basilico, R., Gabrielli, D., Filippone, A. (20019). Magnetic Resonance Assessment of Peritoneal Carcinomatosis: Is There a True Benefit From Diffusion-Weighted Imaging? Current Problems in Diagnostic Radiology. doi: http://doi.org/10.1067/j.cpradiol.2019.06.002

Llueca, A., Serra, A., Rivadulla, I., Gomez, L., Escrig, J. (2018). Prediction of suboptimal cytoreductive surgery in patients with advanced ovarian cancer based on preoperative and intraoperative determination of the peritoneal carcinomatosis index. World Journal of Surgical Oncology, 16 (1). doi: http://doi.org/10.1186/s12957-018-1339-0

Coccolini, F., Catena, F., Glehen, O., Yonemura, Y., Sugarbaker, P. H., Piso, P. et. al. (2015). Complete versus incomplete cytoreduction in peritoneal carcinosis from gastric cancer, with consideration to PCI cut-off. Systematic review and meta-analysis. European Journal of Surgical Oncology (EJSO), 41 (7), 911–919. doi: http://doi.org/10.1016/j.ejso.2015.03.231

Dresen, R. C., De Vuysere, S., De Keyzer, F., Van Cutsem, E., Prenen, H., Vanslembrouck, R. et. al. (2019). Whole-body diffusion-weighted MRI for operability assessment in patients with colorectal cancer and peritoneal metastases. Cancer Imaging, 19 (1). doi: http://doi.org/10.1186/s40644-018-0187-z

Barral, M., Eveno, C., Hoeffel, C., Boudiaf, M., Bazeries, P., Foucher, R. et. al. (2016). Diffusion-weighted magnetic resonance imaging in colorectal cancer. Journal of Visceral Surgery, 153 (5), 361–369. doi: http://doi.org/10.1016/j.jviscsurg.2016.08.004

Engbersen, M. P., van’ t Sant, I., Lok, C., Lambregts, D. M. J., Sonke, G. S., Beets-Tan, R. G. H. et. al. (2019). MRI with diffusion-weighted imaging to predict feasibility of complete cytoreduction with the peritoneal cancer index (PCI) in advanced stage ovarian cancer patients. European Journal of Radiology, 114, 146–151. doi: http://doi.org/10.1016/j.ejrad.2019.03.007

Yuan, X., Guo, L., Du, W., Mo, F., Liu, M. (2017). Diagnostic accuracy of DWI in patients with ovarian cancer. Medicine, 96 (19), e6659. doi: http://doi.org/10.1097/md.0000000000006659

Arslan, H., Fatih Özbay, M., Çallı, İ., Doğan, E., Çelik, S., Batur, A. et. al. (2017). Contribution of diffusion weighted MRI to diagnosis and staging in gastric tumors and comparison with multi-detector computed tomography. Radiology and Oncology, 51 (1), 23–29. doi: http://doi.org/10.1515/raon-2017-0002

Liu, S., Wang, H., Guan, W., Pan, L., Zhou, Z., Yu, H. et. al. (2015). Preoperative apparent diffusion coefficient value of gastric cancer by diffusion-weighted imaging: Correlations with postoperative TNM staging. Journal of Magnetic Resonance Imaging, 42 (3), 837–843. doi: http://doi.org/10.1002/jmri.24841

Coleridge, S. L., Bryant, A., Lyons, T. J., Goodall, R. J., Kehoe, S., Morrison, J. (2019). Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer. Cochrane Database of Systematic Reviews. doi: http://doi.org/10.1002/14651858.cd005343.pub4

Salgado-Ceballos, I., Ríos, J., Pérez-Montiel, D., Gallardo, L., Barquet-Muñoz, S., Salcedo-Hernández, R. et. al. (2017). Is lymphadenectomy necessary in mucinous ovarian cancer? A single institution experience. International Journal of Surgery, 41, 1–5. doi: http://doi.org/10.1016/j.ijsu.2017.03.023

Mengardo, V., Bencivenga, M., Weindelmayer, J., Pavarana, M., Giacopuzzi, S., de Manzoni, G. (2018). Para-aortic lymphadenectomy in surgery for gastric cancer: current indications and future perspectives. Updates in Surgery, 70 (2), 207–211. doi: http://doi.org/10.1007/s13304-018-0549-x

Roze, J. F., Hoogendam, J. P., van de Wetering, F. T., Spijker, R., Verleye, L., Vlayen, J. et. al. (2018). Positron emission tomography (PET) and magnetic resonance imaging (MRI) for assessing tumour resectability in advanced epithelial ovarian/fallopian tube/primary peritoneal cancer. Cochrane Database of Systematic Reviews. doi: http://doi.org/10.1002/14651858.cd012567.pub2

Ong, M. L. H., Schofield, J. B. (2016). Assessment of lymph node involvement in colorectal cancer. World Journal of Gastrointestinal Surgery, 8 (3), 179–192. doi: http://doi.org/10.4240/wjgs.v8.i3.179


👁 417
⬇ 257
Published
2019-12-03
How to Cite
Chetverikov, S., Zavoloka, S., Onyshchenko, V., Chetverikov, M., & Chetverikova-Ovchynnyk, V. (2019). MAGNETIC RESONANCE IMAGING WITH DIFFUSE WEIGHTED IMAGING AND COMPUTED TOMOGRAPHY WITH INTRAVENOUS CONTRAST IN STAGING OF DISSEMINATED OVARIAN, STOMACH, COLORECTAL CANCER. EUREKA: Health Sciences, (6), 59-65. https://doi.org/10.21303/2504-5679.2019.001071
Section
Medicine and Dentistry

Most read articles by the same author(s)