Olga Belousova, Nataliia Kirianchuk, Tetiana Zimnytska


Pathology of the upper digestive tract is the most common among gastroenterological diseases in children of different ages and is 48-50 %. Recently, there has been an increase in combined lesions of the esophagus and organs of the gastroduodenal zone. Currently, microelements are considered to play a role in the etiopathogenesis of the diseases of the gastrointestinal tract.

The aim of the work was to study zinc level in the blood of children with combined gastroesophageal reflux disease (GERD) and chronic gastroduodenal pathology.

Materials and methods. 110 children with combined GERD and lesions of the gastroduodenal zone at the age of 10–18 years were under observation. In order to verify the diagnosis, esophagogastroduodenoscopy was performed. The level of zinc in the blood of children was studied using photometric method.

Results. 52.5 % of children with concomitant GERD and chronic gastroduodenal pathologies had a reduced zinc level in the blood. According to the results of the study, the risk factors of zinc deficiency in children with combined pathology of the upper digestive tract include male sex, age older than 14 years, the duration of the disease longer than 3 years. The level of zinc in the blood of children was significantly reduced in destructive lesions of the esophagus, as well as with more pronounced inflammation of the gastric mucosa, in duodenitis and erosions in the duodenal bulb.

Conclusions. Thus, the results of the study showed the importance of studying the level of zinc in the blood of patients with combined GERD and chronic gastroduodenal pathology to achieve positive changes by its correction. Zinc deficiency more often develops in boys over 14 year old, who has inflammatory changes of digestive tract.


gastroesophageal reflux disease; chronic gastroduodenal pathology; children; zinc

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Pavlenko, N. V., Shutova, O. V., Hanzii, O. B., Solodovnichenko, I. G., Savytska, K. V., Slobodianiuk, O. L. (2018). Optimization of eradication treatment for chronic gastroduodenitis associated with Helicobacter pylori in children using spore recombinant probiotic based on Bacillus subtilis. Child`s Health, 13, s16–s22. doi:

Pavlenko, N. V., Solodovnichenko, I. G., Voloshin, K. V., Ganziy, E. V. (2013). Combined pathology of the esophagus and gastroduodenal zone in children: changing priorities. Perinatologiya i Pediatriya, 4, 85–87.

Plockireva, A. A. (2011). Nutritive approaches to the correction and prophylaxis of microelemental status disorders in children. Current Pediatrics, 10 (2), 141–145.

Agarwal, A., Khanna, P., Baidya, D. K., Arora, M. K. (2011). Trace Elements in Critical Illness. Journal of Endocrinology and Metabolism, 1 (2), 57–63. doi:

Tarasova, L. V. (2012). The role of selenium, zinc, manganese in the pathogenesis of chronic gastritis and ulcerous disease of duodenum. Medical Almanac, 2, 234–239.

Prasad, A. S. (2013). Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease. Advances in Nutrition, 4 (2), 176–190. doi:

Marushko, Y. V., Asonov, A. O. (2015). Clinical significance of zinc deficiency in children with chronic gastroduodenitis associated with Helicobacter pylori. Children’s doctor, 3-4, 5–8.

Marushko, Yu. V., Asonov, A. O., Gichka, S. G. (2014). Features of clinical course of chronic gastroduodenitis, morphological changes and gastroprotection state in children with zinc deficiency. Child`s health, 4, 7–12.

Skrovanek, S., DiGuilio, K., Bailey, R., Huntington, W., Urbas, R., Mayilvaganan, B., Mullin, J. M. (2014). Zinc and gastrointestinal disease. World Journal of Gastrointestinal Pathophysiology, 5 (4), 496–513. doi:

Podobed, V. M. (2015). Zinc Сarnosin: a new formula of gastroprotection and making up zinc deficiency. Medical news, 2, 17–20.

Gaby, A. (2017). Nutritional medicine. Concord, NH: Fritz Perlberg Publishing.

Marushko, Y. V., Asonov, A. O. (2013). Gastroprotection study in children with chronic gastroduodenitis and zinc deficiency. Journal of the Grodno State Medical University, 4, 87–90.

Sannikova, N. E., Shagiakhmetova, L. V., Osheva, T. M. (2007). Essential trace elements status of children and adolescents suffering chronic gastroduodenitis. Pediatric Nutrition, 5 (5), 12–17.

Bulatov, V. P., Rylova, N. V. (2010). The mineral status at children with digestive diseases. Practical medicine, 3, 26–30.

Ozturk, N., Kurt, N., Ozgeris, F. B., Kilic Baygutalp, N., Tosun, M. S., Bakan, N., Bakan, E. (2015). Serum Zinc, Copper, Magnesium and Selenium Levels in Children with Helicobacter Pylori Infection. The Eurasian Journal of Medicine, 47 (2), 126–129. doi:

Valenzano, M. C., Mercado, J. M., Wang, X., Zurbach, E. P., Raines, J., McDonnell, E. et. al. (2014). Drug delivery of zinc to Barrett’s metaplasia by oral administration to Barrett’s esophagus patients. Therapeutic Delivery, 5 (3), 257–264. doi:

Shafaghi, A., Hasanzadeh, J., Mansour-Ghanaei, F., Joukar, F., Yaseri, M. (2016). The Effect of Zinc Supplementationon the Symptoms of Gastroesophageal Reflux Disease; a Randomized Clinical Trial. Middle East Journal of Digestive Diseases, 8 (4), 289–296. doi:

Johnsen, Ø., Eliasson, R. (1987). Evaluation of a commercially available kit for the colorimetric determination of zinc in human seminal plasma. International Journal of Andrology, 10 (2), 435–440. doi:

Nakaz Ministerstva okhorony zdorovia Ukrainy N 59 (29.01.2013). Unifikovanyi klinichnyi protokol medychnoi dopomohy ditiam iz hastroezofahealnoiu refliuksnoiu khvoroboiu. Sovremennaya pediatriya, 4, 20–31.

Gammoh, N. Z., Rink, L. (2017). Zinc in infection and inflammation. Nutrients, 9 (6), 624. doi:



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