VITAMIN D AS ONE OF PREDICATORS OF THE STABLE VIRAL RESPONSE TO ANTIVIRAL THERAPY IN PATIENTS WITH CHRONIS HEPATITIS С
Abstract
Chronic hepatitis C (CHC) it is not exceptionally medical problem but a significant social and economic threat, taking into account the unfavorable consequences of this disease: cirrhosis and hepatocellular carcinoma. And as a result - the high level of disability. In the article are presented the results of examination of 41 patients with chronic hepatitis C, with 1 genotype, who received the antiviral therapy (AVT). All patients underwent determination of the level of 5-hydroxycholeсalсeferol (25-OH vit D3), vitamin D and also the study of IL-28B polymorphism as the one of predicators of response to AVT. It was demonstrated, that in patients with hepatitis was observed the deficit of 25-OH vit D3 and general vitamin D. It was established, that in patients with the normal 25-OH vit D3 level SVR (stable viral response) was observed in 1,4 times more often than in patients with deficit of 25-OH vit D3. That is the level of 25-OH vit D3 can be considered as a predicator of SVR to AVT.
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References
WHO Bulletin (2014). World Health Organization, 164.
Golubovska, O. A., Lischyshyna, O. M., Andreychyn, M. A. et. al. (2014). Viral Hepatitis C: Clinical adapted guidance based on evidence. The application to the Ministry of Health of Ukraine 02.04.2014; № 233, 90.
Wovk, A. D. (2007). Clinical problem and the treatment of chronic hepatitis C. Ukr. med. Journal, 1, 50–54.
Ghany, M. G., Strader, D. B., Thomas, D. L., Seeff, L. B. (2008). Diagnosis, management, and treatment of hepatitis C: An update. Hepatology, 49 (4), 1335–1374. doi: 10.1002/hep.22759
Mauss, S., Berg, T., Rockstroh, J. et. al. (2012). Short Guide to Hepatitis C. Flying Publisher, 150.
Ignatova, T. M., Aprosina, Z. G., Serov, V. V. (2001). Extrahepatic manifestations of chronic HCV-infection. Rus. Med. Journal, 2, 13–18.
Anastasiy, I. A. (2007). World experience in the treatment of patients with chronic hepatitis C. Infectious diseases, 3, 102–103.
Agnello, V., De Rosa, F. G. (2004). Extrahepatic disease manifestations of HCV infection: some current issues. Journal of Hepatology, 40 (2), 341–352. doi: 10.1016/j.jhep.2003.10.009
Guida, M., D’Elia, G., Benvestito, S., Casamassima, A., Micelli, G., Quaranta, M. et. al. (2002). Hepatitis C virus infection in patients with B-cell lymphoproliferative disorders. Leukemia, 16 (10), 2162–2163. doi: 10.1038/sj.leu.2402626
Bueverov, A. O., Maevskaya, M. V. (2008). Chronic hepatitis C and associated liver pathology. Clinic. prospects. gastroenterol. hepatol, 6, 9–15.
Shakhgildyan, I. V., Jasinski, A. A., Mikhailov, M. I. et. al. (2008). Chronic hepatitis in the Russian Federation. Epidemiology and Infectious Diseases, 6, 12–15.
Iacob, S. A., Banica, D., Panaitescu, E. et. al. (2010). Positive correlation of 25-hydroxyvitamin D plasma level and T helper activity in chronic hepatitis C patients. International Journal of Biology and Biomedical engineering, 4 (2), 43–51.
Arteh, J., Narra, S., Nair, S. (2009). Prevalence of Vitamin D Deficiency in Chronic Liver Disease. Digestive Diseases and Sciences, 55 (9), 2624–2628. doi: 10.1007/s10620-009-1069-9
Rahman, A. H., Branch, A. D. (2013). Vitamin D for your patients with chronic hepatitis C? Journal of Hepatology, 58 (1), 184–189. doi: 10.1016/j.jhep.2012.07.026
Ladero, J. M., Torrejon, M. J., Sanchez-Pobre, P. (2013). Vitamin D deficiency and vitamin D therapy in chronic hepatitis C. Annals of Hepatology, 12, 199–204.
Suppiah, V., Moldovan, M., Ahlenstiel, G., Berg, T., Weltman, M., Abate, M. L. et. al. (2009). IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy. Nature Genetics, 41 (10), 1100–1104. doi: 10.1038/ng.447
Pampukha, V. M., Kravchenko, S. A., Moroz, L. V., Livshits, L. A. (2011). IFN-λ-3 (IL28B) genotyping by restriction fragment length polymorphism method: detection polymorphism of rs12979860. Biopolymers and Cell, 27 (3), 231–234. doi: 10.7124/bc.0000be
Gal-Tanamy, M., Bachmetov, L., Ravid, A., Koren, R., Erman, A., Tur-Kaspa, R., Zemel, R. (2011). Vitamin D: An innate antiviral agent suppressing hepatitis C virus in human hepatocytes. Hepatology, 54 (5), 1570–1579. doi: 10.1002/hep.24575
Corey, K. E., Zheng, H., Mendez-Navarro, J., Delgado-Borrego, A., Dienstag, J. L., Chung, R. T. (2012). Serum Vitamin D Levels Are Not Predictive of the Progression of Chronic Liver Disease in Hepatitis C Patients with Advanced Fibrosis. PLoS ONE, 7 (2), e27144. doi: 10.1371/journal.pone.0027144
Gutierrez, J., Parikh, N., Branch, A. (2011). Classical and Emerging Roles of Vitamin D in Hepatitis C Virus Infection. Seminars in Liver Disease, 31 (04), 387–398. doi: 10.1055/s-0031-1297927
Copyright (c) 2016 Larisa Moroz, Eltun Engibar Ogli Musaev, Olga Androsova, Irina Davydyuk
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