RESEARCH ON THE SELECTION OF EXCIPIENTS AS THE RATIONALE FOR THE COMPOSITION OF THE TABLETS WITH DRY EXTRACT OF SANGUISORBA OFFICINALIS

Lyudmila Shulga, Kateryna Bezkrovna, Nina Domar

Abstract


The aim. The aim of the research was to study the effect of different groups of excipients on the pharmaco-technological propertiesof the powder mass for tabletting in the development of the composition of the tablets with dry extract of Sanguisorba officinalis for complex therapy of the gastrointestinal tract diseases.

Materials and methods. Objects of study - dry extract Sanguisorba officinalis, 25 excipients used in the production of tablets by the method of direct compression, grouped into five groups of factors (fillers based on sugars and microcrystalline cellulose, disintegrants, glidants and lubricants), samples of powder masses. Studies on the determination of pharmaco-technological properties (fluidity, bulk density, bulk density after shrinkage, degree of compressibility, Hausner ratio, and angle of repose) of the obtained powder masses were carried out according to the methods of the State Pharmacopoeia of Ukraine, Second edition. The method of mathematical planning of the experiment was used in the work, the obtained results were subjected to variance analysis, and the ranked series of advantages were placed, in which the excipients were placed in the sequence of their influence on the studied pharmaco-tecnological parameters.

Results and discussion. The influence of excipients (factors) on the pharmaco-technological properties (responses) of the powdered tablet masses with the construction of ranked benefits was studied using a five-factor experiment, a hyper-Graeco-Latin square. The results of the analysis of variance showed that glidants have the greatest influence on the fluidity, the bulk density and the bulk density after shrinkage. Neusilin US 2 significantly affects the fluidity of the powder masses and Hausner ratio, the talc having the greatest effect on the bulk density and the bulk density after shrinkage of the powder masses. The representative of the disintegrants group – Sodium starch glycolate most influences the compressibility index, the sugar-based filler – Pearlitol 500 DC – on the angle of repose.

Conclusions. The effect of 25 excipients on the pharmaco-technological characteristics of the powdered tablet masses with dry extract of Sanguisorba officinalis was studied. It was found that among the sugars-based fillers equally good results were shown in the powder masses with Compri sugar, Tablettose 80 and Pearlitol 500 DC; among the microcrystalline cellulose based fillers is Prosolv 90; among glidants – Neusilin US 2; no comparison was made of the disintegrants and lubricant excipients from the studied list of leader substances. The results of the studies indicate the possibility of obtaining tablets by the direct compression method, and further study of their pharmaco-technological characteristics will allow to establish the optimal composition of excipients.


Keywords


Sanguisorba officinalis; dry extract; excipients; powder masses; mathematical planning of the experiment; tablets

Full Text:

PDF

References


Mezentseva, N. I., Batychenko, S. P., Mezentsev, K. V. (2018). Zakhvoriuvanist i zdorovia naselennia v Ukraini: suspilno-heohrafichnyi vymir. Kyiv: DP «Print Servis», 136.

Sambukova, T. V., Ovchinnikov, B. V., Ganapol’sky, V. P., Yatmanov, A. N., Shabanov, P. D. (2017). Prospects for phytopreparations (botanicals) use in modern pharmacology. Reviews on Clinical Pharmacology and Drug Therapy, 15 (2), 56–63. doi: http://doi.org/10.17816/rcf15256-63

Triantafyllidi, A., Xanthos, T., Papalois, A., Triantafillidis, J. K. (2015). Herbal and plant therapy in patients with inflammatory bowel disease. Annals of Gastroenterology, 28 (2), 210–220.

Kelber, O., Bauer, R., Kubelka, W. (2017). Phytotherapy in Functional Gastrointestinal Disorders. Digestive Diseases, 35 (1), 36–42. doi: http://doi.org/10.1159/000485489

Shulha, L. I., Bezkrovna, K. S., Peresadko, I. H. (2017). Zastosuvannia rodovyka likarskoho u narodnii i ofitsiinii medytsyni – bazys novykh farmatsevtychnykh rozrobok. Zbirnyk naukovykh prats spivrobitnykiv NMAPO im. P. L. Shupyka, 27, 173–185.

Shulga, L. I., Bezkrovna, K. S., Beztsenna, T. S. (2018). Analysis of the segment of phytomedicines for the treatment of diseases of the gastrointestinal tract on the pharmaceutical market of Ukraine. Pharmaceutical Review, 1, 93–101. doi: http://doi.org/10.11603/2312-0967.2018.1.8699

Bezkrovna, K. S., Shulga, L. I., Domar, N. A. (2019). Pharmaco-technological and thermogravimetric researches of burnet roots in optimization of the process of obtainment of extract dry. Norwegian Journal of development of the International Science, 36 (2), 44–49.

Bezkrovnaia, E. S., Shulga, L. I., Faizullin, A. V., Krasilnikova, O. A. (2019). Izuchenie protivoiazvennogo deistviia sukhogo ekstrakta krovokhlebki. Sovremennye dostizheniia farmatsevticheskoi nauki i praktiki. Vitebsk: «VGMU», 232–233.

Shulga, L. I., Bezkrovna, K. S., Soldatov, D. P., Osolodchenko, T. Р. (2019). Burnet roots extract dry: study of pharmaco-technological and antibacterial properties. Annals of Mechnikov Institute, 3, 39–43. doi: http://doi.org/10.5281/zenodo.3469428

Helmis, M., Mohamad, B., Kumpugdee-Vollrath, M. (2016). Influence of Several Excipients on Drug Release of Tablets Containing Resveratrol. Mathews Journal of Pharmaceutical Science, 1 (2), 007.

Allamneni, N., Suresh, J. N. (2014). Co-Processed Excipients as a new generation excipients with multifunctional activities: An overview. Indian Journal of Pharmaceutical Science and Research, 4 (1), 22–25.

Bhor, N. J., Bhusare, S. E., Kare, P. T. (2014). Multifunctional Excipients: The Smart Excipients. International Journal of Pure & Applied Bioscience, 2 (5), 144–148.

Derzhavna Farmakopeia Ukrainy. Vol. 1 (2015). Kharkiv: Derzhavne pidpryiemstvo «Ukrainskyi naukovyi farmatsevtychnyi tsentr yakosti likarskykh zasobiv», 1128.

Ruban, О., Alkhalaf, M., Gerbina, N. (2019). Selection of a filler for tablets manufactured with direct compression method containing dry ginger extract. EUREKA: Health Sciences, 3, 26–34. doi: http://doi.org/10.21303/2504-5679.2019.00904

Kambarov, Kh. Zh., Usubbaev, A. M. (2012). Razrabotka sostava i tekhnologii tabletok «Tselitel Vostoka». Vestnik farmatsii, 2 (56), 45–49.

Ruban, O. A., Kolisnyk, T. Y., Slipchenko, G. D. (2018). Application of experimental design method in optimization of composition and technology for matrix tablets containing Vaccinium myrtillus leaf dry extract. Pharmaceutical Review, 2, 41–47. doi: http://doi.org/10.11603/2312-0967.2018.2.9003

Hroshovyi, T. A., Martseniuk, V. P., Kucherenko, L. I., Vronska, L. V., Hureieva, S. M. (2008). Matematychne planuvannia eksperymentu pry provedenni naukovykh doslidzhen v farmatsii. Ternopil: Ukrmedknyha, 377.

Darzuli, N., Hroshovyi, T., Sokolova, K., Podpletnyaya, E. (2018). Investigation of the effects of excipients on technological properties tablets of Pyrola rotundifolia extract. ScienceRise: Pharmaceutical Science, 2 (12), 43–48. doi: http://doi.org/10.15587/2519-4852.2018.128046

Ruban, O. A., Pertsev, I. M., Kutsenko, S. A., Maslii, Yu. S.; Pertseva, I. M. (Ed.) (2016). Dopomizhni rechovyny u vyrobnytstvi likiv. Kharkiv: Zoloti storinky, 720.

Darzuli, N., Budniak, L., Hroshovyi, T. (2019). Selected excipients in oral solid dosage form with dry extract of Pyrola rotundifolia L. International Journal of Applied Pharmaceutics, 11 (6), 210–216. doi: http://doi.org/10.22159/ijap.2019v11i6.35282

Barchuk, O. Z., Groshovyi, T. A., Zaliska, O. M., Shalata, V. J., & Revyatsky, I. Y. (2017). Development of optimal composition and technology of tablets based on the exstract of goat’s rue herb, extract of bilberry leaves and taurine by direct compression method. Pharmaceutical Review, 4, 30-40. doi: http://doi.org/10.11603/2312-0967.2017.4.8352




DOI: http://dx.doi.org/10.21303/2504-5679.2020.001195

Refbacks

  • There are currently no refbacks.




Copyright (c) 2020 Lyudmila Shulga, Kateryna Bezkrovna, Nina Domar

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

ISSN 2504-5679 (Online), ISSN 2504-5660 (Print)