USE OF METHODS OF MATHEMATIC STATISTICS FOR PROCESSING OF MEDICAL-BIOLOGICAL DATA FOR REVELATION OF THE ROLE OF CHEMICAL ELEMENTS IN ETHIOPATHOGENESIS OF HUMAN DISEASES

  • Anatolij Prykhodchenko Dneprodzerzhinsk Institute of Economic and Management, Ukraine
  • Yulia Ulianovska University of Customs and Finance, Ukraine
  • Vladislav Ulianoskiy Zaporozhye State Medikal University., Ukraine
Keywords: hematopoietic system, leukoconcentrate venous blood, correlation analysis, regression analysis

Abstract

Aim of paper was to appraise the possibility of use of the traditional mathematical statistics methods for biomedical data to processing for determining the role of aluminium, chrome, niobium and lead in functioning of human blood-forming system. An effect of the abovementioned microelements on immunocompetent and blast cells was examined.

Methods. To solve the indicated purposes, it were examined the venous blood leukoconcentrate in 48 of the examined persons. The standard methods of statistics were applied to the obtained data, namely the construction of spreading plot, elements of correlation and regression analysis.

Results. It was obtained, that the reaction of immunocompetent and blast cells is ambivalent and depends upon the level of micronutrient status in human organism. Micronutrient biogenic effect is observed upon its low concentration in blood. An abiogenic effect arises upon the high level of micronutrient status in biological media of human.

Conclusions. Notwithstanding the obtained results, the generally accepted approaches haven’t provided the possibility to determine the faithful character of immunocompetent and blast cells reaction on the level of micronutrient status in human organism and require the elaboration and development of the new approaches considering the revealed nonlinear relation.

Downloads

Download data is not yet available.

Author Biographies

Anatolij Prykhodchenko, Dneprodzerzhinsk Institute of Economic and Management

Department of Ecological Management

Yulia Ulianovska, University of Customs and Finance

Department of Information Systems and Technology

Vladislav Ulianoskiy, Zaporozhye State Medikal University.

Student of I medical department

References

Noli, F., Tsamos, P. (2016). Concentration of heavy metals and trace elements in soils, waters and vegetables and assessment of health risk in the vicinity of a lignite-fired power plant. Science of The Total Environment, 563-564, 377–385. doi: 10.1016/j.scitotenv.2016.04.098

Das, S., Raj, R., Mangwani, N., Dash, H. R., Chakraborty, J. (2014). Heavy Metals and Hydrocarbons. Microbial Biodegradation and Bioremediation, 23–54. doi:10.1016/b978-0-12-800021-2.00002-9

Ibrahim, D., Froberg, B., Wolf, A., Rusyniak, D. E. (2006). Heavy Metal Poisoning: Clinical Presentations and Pathophysiology. Clinics in Laboratory Medicine, 26 (1), 67–97. doi: 10.1016/j.cll.2006.02.003

Antamonov, М. Yu. Matematicheskie aspekty analiza dannyh v medico-ekologicheskih issledovaniyah. Aviailableat: http://www.health.gov.ua/publ/conf.nsf/50e0ce97d91c75b3c2256d8f0025c386/c2e9d1e8ae70d844c2256dc6003f7ea3?OpenDocument

Lakin, G. F. (1990). Biometriya. Moscow: Vyshayashkola, 352.

Antamonov, М. Yu. (2006). Мatematicheskaya obrabotka I analiz medico-biologicheskih dannyh. Kyiv: Malydruk, 558.

Pashinska, S. L., Antamonov, M. Yu. (2014). Tehnologiya rozrahunku ta analizu integralnyh pokaznykiv dlia ocinky ekologo-gigienichnyh ob’ektiv. Molody vcheny. Biologichni nauky, 8 (11), 10–12.

Haschek, W. M., Rousseaux, C. G., Wallig, M. A. (2010). Hematopoietic System. Fundamentals of Toxicologic Pathology, 491–512. doi: 10.1016/b978-0-12-370469-6.00016-7

Di Gioacchino, M., Petrarca, C., Perrone, A., Farina, M., Sabbioni, E., Hartung, T. et. al. (2008). Autophagy as an ultrastructural marker of heavy metal toxicity in human cord blood hematopoietic stem cells. Science of The Total Environment, 392 (1), 50–58. doi: 10.1016/j.scitotenv.2007.11.009

Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H. et. al. (2008). Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death and Differentiation, 16 (1), 3–11. doi: 10.1038/cdd.2008.150

Kerr, J. F. R., Wyllie, A. H., Currie, A. R. (1972). Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. British Journal of Cancer, 26 (4), 239–257.

Cohen, M. M. (1980). Neurotoxic effects of heavy metals and metalloids. Biochemistry of Brain, 453–468. doi: 10.1016/b978-0-08-021345-3.50020-4

Huang, C.-C. (2007). Parkinsonism Inducedby Chronic Manganese Intoxication– An Experience in Taiwan. Chang Gung Med Journal, 30 (5), 385–395.

Shafran, L. M., Gozhenko A. I. (2009). Professionalno obuslovlenye metallonefropatii na transporte: etiopatoginez, diagnostika, profilaktika. Bulleten VCNC SO RAMN, 1 (65), 141–146.

Tomilin, N. V., Petrov, A. N., Filko, O. A., Khrabrova, A. V., Solovyeva, N. E., Ivanova, T. M. et. al. (2015). Ocenka stepeni povrezhdeniya yaderniy DNK v kletkah perefericheskoy krovi ludey proffesionalno sviazanyh s deystviem tiazhelyh metallov. Organizacija zdravohranienija, 16, 383–392. Available at: http://www.medline.ru/public/art/tom16/art37.html

Kasirski, I. A., Alekseev, G. A. (1955). Klinicheskaya gematologia. Мoscow: Medgiz, 720.

Pospelova, R. A. (1973). Leykokoncentracia v klinicheskoy praktike, diagnosticheskoe znacenie. Мoscow: Medicina, 21.

Prihodchenko, А. А. (1992). Issledovanie leykokoncentratia venoznoy krovi v klinicheskoy ekologii. Metodika issledovatelskaya. Мoscow: NPO «Vektor», 28.

Yaderno-fizicheskie metody. Instrukcia № 194 – YaF. (1982). Rentgenoradiometricheskoe opredelenie elementov s primeneniem poluprovodnikovogo spektrometra. Мoscow: VIMS, 21.

Trace element reference materials for clinical research and diagnostics. Available at: http://www.lgcstandards.com/ZR/en/

Gmurman, V. E. (2001). Teoriya veroyatnostey I matematicheskaya statistika. Мoscow: Vyshayashkola, 479.

Tolbatov, Yu. А. (1997). Ekonometrika. Kyiv: Chetvertahvylia, 320.


👁 399
⬇ 379
Published
2016-08-10
How to Cite
Prykhodchenko, A., Ulianovska, Y., & Ulianoskiy, V. (2016). USE OF METHODS OF MATHEMATIC STATISTICS FOR PROCESSING OF MEDICAL-BIOLOGICAL DATA FOR REVELATION OF THE ROLE OF CHEMICAL ELEMENTS IN ETHIOPATHOGENESIS OF HUMAN DISEASES. EUREKA: Health Sciences, (4), 49-56. https://doi.org/10.21303/2504-5679.2016.00132
Section
Medicine and Dentistry