COMPARATIVE ANALYSIS OF THE EFFECTIVENESS OF CHRONOTHERAPY AND TRADITIONAL METHOD OF ALOPECIA AREATA TREATMENT

Nikolay Polischuk, Ilya Polischuk

Abstract


Alopecia areata – is the one of widespread baldness forms, difficultly subjected to treatment. The method of chronotherapy that gains an essential circulation in Ukraine and throughout the world may play the important role in its solution.

Aim: to study the clinical effectiveness of chronotherapy for alopecia areata treatment.

Materials and methods. For attaining the set aim 108 persons with the diagnosis alopecia areata were examined and treated. Patients were divided in two groups. The main group included 45 persons – treated using the method of chronotherapy. The control group consisted of 67 persons, who received the traditional treatment of alopecia areata. The series of clinical, biochemical and immunological studies, directed on the assessment of the treatment effectiveness, were realized.

Results. The treatment of patients with alopecia areata by the method of chronotherapy is statistically reliably more effective than the traditional treatment of this pathology and provides the renewal of hair growth in 53,3 % of patients that is accompanied by normalization of alexin, sulfhydryl groups content, acid phosphatase activity, serine, asparagine acid, valine, threonine, alanine, cystine, leucine, isoleucine concentrations. The offered chronotherapy method has the expressed anabolic effect on patients’ organism. The menstrual cycle is normalized, pre-menstrual syndrome symptoms and aldodysmenorrhea disappear, patients’ working ability and state of health improve.

Conclusions. The obtained data deepen knowledge about the pathogenesis of alopecia areata at the biochemical and immunological levels and favor the rise of the effectiveness of diagnostics and treatment of this pathology. At the study the high chronotherapy effectiveness at treating alopecia areata was revealed and the possibility of its use for the effective treatment of a series of other pathologies was proved. 


Keywords


chronotherapy; traditional treatment method; alopecia areata; treatment effectiveness; immunological indices; biochemical indices

Full Text:

PDF

References


Soloshenko, E. N. (2009). Clinical varieties of alopecia: pathogenesis, differential diagnosis, therapy. International Medical Journal, 1, 102–109.

Wang, E., Mcelwee, K. J. (2011). Etiopathogenesis of alopecia areata: Why do our patients get it? Dermatologic Therapy, 24 (3), 337–347. doi: 10.1111/j.1529-8019.2011.01416.x

Olisova, O. Yu., Verkhozhdory, I. V., Gostroverkhova, I. P. (2010). Contemporary notions about etiology, pathogenesis and treatment of focal alopecia. Journ Skin and venereal diseases, 1, 48–52.

Serbina, I. M. (2014). Cytokine-mediated mechanisms of formation of alopecia areata. Scientific bulletins of BelSU. Series: Medicine. Pharmacia, 28 (24 (195)), 32–38.

Boger, Ts. M. (2000). Duration of drugs and moon phases. Krivoy Rog: Rimedia Gomeo, 108.

Degtyareva, Z. Ya., Moiseev, N. I., Fedoseev, G. B. (1981). Chronobiological approach in the clinic and therapy of bronchial asthma. Chronobiology and Chronopathology. Moscow, 923.

Smolensky, M. H., Hermida, R. C., Ayala, D. E., Tiseo, R., Portaluppi, F. (2010). Administration–time-dependent effects of blood pressure-lowering medications: basis for the chronotherapy of hypertension. Blood Pressure Monitoring, 15 (4), 173–180. doi: 10.1097/mbp.0b013e32833c7308

Hermida, R. C., Ayala, D. E., Calvo, C., Portaluppi, F., Smolensky, M. H. (2007). Chronotherapy of hypertension: Administration-time-dependent effects of treatment on the circadian pattern of blood pressure. Advanced Drug Delivery Reviews, 59 (9-10), 923–939. doi: 10.1016/j.addr.2006.09.021

Huangfu, W., Duan, P., Xiang, D., Gao, R. (2015). Administration time-dependent effects of combination therapy on ambulatory blood pressure in hypertensive subjects. International Journal of Clinical and Experimental Medicine, 8 (10), 19156–19161.

Hermida, R. C., Ayala, D. E., Mojon, A., Fontao, M. J., Fernandez, J. R. (2011). Chronotherapy With Valsartan/Hydrochlorothiazide Combination in Essential Hypertension: Improved Sleep-Time Blood Pressure Control With Bedtime Dosing. Chronobiology International, 28 (7), 601–610. doi: 10.3109/07420528.2011.589935

Ciappi, G., De Benedetto, F., D'Illario, F. et. al. (1982). Chronobiological aspects of bronchial tone. Chronobiologia, 9 (2), 163–172.

Hetzel, M. R., Clark, T. J. (1980). Comparison of normal and asthmatic circadian rhythms in peak expiratory flow rate. Thorax, 35 (10), 732–738. doi: 10.1136/thx.35.10.732

Sigurdardottir, L. G., Valdimarsdottir, U. A., Fall, K., Rider, J. R., Lockley, S. W., Schernhammer, E., Mucci, L. A. (2012). Circadian Disruption, Sleep Loss, and Prostate Cancer Risk: A Systematic Review of Epidemiologic Studies. Cancer Epidemiology Biomarkers & Prevention, 21 (7), 1002–1011. doi: 10.1158/1055-9965.epi-12-0116

Lengyel, Z., Battyani, Z., Szekeres, G., Csernus, V., Nagy, A. D. (2013). Circadian clocks and tumor biology: What is to learn from human skin biopsies? General and Comparative Endocrinology, 188, 67–74. doi: 10.1016/j.ygcen.2013.03.033

Relogio, A., Thomas, P., Medina-Perez, P., Reischl, S., Bervoets, S., Gloc, E. et. al. (2014). Ras-Mediated Deregulation of the Circadian Clock in Cancer. PLoS Genetics, 10 (5), e1004338. doi: 10.1371/journal.pgen.1004338

Khapre, R. V., Samsa, W. E., Kondratov, R. V. (2010). Circadian regulation of cell cycle: Molecular connections between aging and the circadian clock. Annals of Medicine, 42 (6), 404–415. doi: 10.3109/07853890.2010.499134

Garanyan, L. G. (2015). Melatonin preparations in dermatological practice. Russian journal of skin and venereal diseases, 18 (6), 50–52.

Borodin, Yu. I., Trufakin, V. A., Michurina, S. V., Shurlygina, A. V. (2012). Structural and temporal organization of liver, lymphatic, immune and endocrine systems in violation of the light regime and the administration of melatonin. Novosibirsk: Manuskript, 207.

Cutolo, M. (2012). Chronobiology and the treatment of rheumatoid arthritis. Current Opinion in Rheumatology, 24 (3), 312–318. doi: 10.1097/bor.0b013e3283521c78

Li, W.-Q., Qureshi, A. A., Schernhammer, E. S., Han, J. (2013). Rotating Night-Shift Work and Risk of Psoriasis in US Women. Journal of Investigative Dermatology, 133 (2), 565–567. doi: 10.1038/jid.2012.285




DOI: http://dx.doi.org/10.21303/2504-5679.2017.00415

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 Nikolay Polischuk, Ilya Polischuk

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

ISSN 2504-5679 (Online), ISSN 2504-5660 (Print)