Leonid Bezrukov, Olena Koloskova, Olena Vlasova


An advanced progress of clinical neonatology in recent years has enabled to achieve considerable success in newborn management with due respect to both medical treatment and general care, especially in the group of neonates with low body weight at birth. At the same time, neonatal sepsis in the early period still predetermine sickness and mortality of newborns.

Material and methods. Clinical-paraclinical indices with detection of diagnostic value of C-reactive protein and interleukins-6 and 8 were evaluated in 100 neonates with available susceptibility factors to early neonatal infection from mother’s side and clinical signs of organ dysfunction in neonates with precautions of generalized infectious-inflammatory process at the end of their first day of life.

Results. The data obtained substantiate that low concentrations of IL-6 and IL-8 prevail, and therefore the mentioned mediators hardly can be used to verify early neonatal infection. In the majority of children C-reactive protein elevated the concentration of 10.0 mg/L which is traditionally considered to be a discriminant as to the verification of an infectious process in newborns.

Conclusions. None of the clinical signs associated with infectious-inflammatory process in newborns in the first two days of their life enabled to verify reliably availability of systemic bacterial infection.


neonatal sepsis; C-reactive protein; interleukin-6 and 8; parameters of diagnostic value

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Kliegman, R. H., Starton, B. F. (2016). Etiology of Fetal and Neonatal Infection. Nelson Textbook of Pediatrics. Saunders, 20, 169–202.

Stoll, B., Kliegman, R. M., Beharman, R. E.; Kliegman, R. M., Behrman, R. E., Jenson, H. B, Stanton, B. F. (Eds.) (2008). Infections in neonates: Etiology of fetal and neonatal infection. Nelson text book of pediatrics 18th ed., 794–811.

Surkov, D. N., Surkova, A. D., Ivanov, D. O. (2014). Epidemiologiya neonatal'nogo sepsisa: analiz raboty otdeleniya intensivnoi terapii dlya novorozhdennyh [Epidemiology of neonatal sepsis: analysis of the intensive care unit for neonates]. Vestnik sovremenno klinicheskoi mediciny, 7 (6), 56–61.

Golubova, Yu. M., Dekhtyarov, D. N. (2014). Sovremennyi podhody k profilaktike, diagnostike i lecheniyu rannego neonatal'nogo sepsisa [Modern approaches to the prevention, diagnosis and treatment of early neonatal sepsis]. Neonatologiya: novosti, klinika, obuchenie, 2, 10–16.

Yacyk, G. V. (2009). Sepsis novorozhdennyh. Sovremennye problemy diagnostiki i lecheniya [Sepsis of newborns. Modern problems of diagnosis and treatment]. Praktika pediatra, 2, 6–9.

Abd Elaziz, H. (2013). Diagnosis of Neonatal using different sepsis markers. Abstract. 4th International Conference on Biomarkers and Clinical Research. Philadelphia, 17.

Remick, D. G. (2007). Pathophysiology of Sepsis. The American Journal of Pathology, 170 (5), 1435–1444. doi: http://doi.org/10.2353/ajpath.2007.060872

Hendricks-Munoz, K., Xu, J., Mally, P. (2014). Biomarkers for neonatal sepsis: recent developments. Research and Reports in Neonatology, 4, 157–168. doi: http://doi.org/10.2147/rrn.s48316

Al-Zahrani, A. K., Ghonaim, M. M., Hussein, Y. M., Eed, E. M., Khalifa, A. S., Dorgham, L. S. (2015). Evaluation of recent methods versus conventional methods for diagnosis of early-onset neonatal sepsis. The Journal of Infection in Developing Countries, 9 (4), 388–393. doi: http://doi.org/10.3855/jidc.5950

Prashant, A., Vishwanath, P., Kulkarni, P., Sathya Narayana, P., Gowdara, V., Nataraj, S. M., Nagaraj, R. (2013). Comparative Assessment of Cytokines and Other Inflammatory Markers for the Early Diagnosis of Neonatal Sepsis–A Case Control Study. PLoS ONE, 8 (7), e68426. doi: http://doi.org/10.1371/journal.pone.0068426

Shahkar, L., Keshtkar, A., Mirfazeli, A., Ahani, A., Roshandel, G. (2011). The Role of IL-6 for Predicting Neonatal Sepsis: A Systematic Review and Meta-Analysis. Iranian Journal of Pediatrics, 21 (4), 411–417.

Kafetzis, D. A., Tigani, G. S., Costalos, C. (2005). Immunologic markers in the neonatal period: diagnostic value and accuracy in infection. Expert Review of Molecular Diagnostics, 5 (2), 231–239. doi: http://doi.org/10.1586/14737159.5.2.231

Kostiuk, O. O. (2010). Perynatalna infektsiia, sprychynena streptokokom hrupy V [Perinatal infection caused by Streptococcus group B]. Kyiv: Natsionalna medychna akademiia pisliadyplomnoi osvity imeni P. L. Shupyka, 120.

Kornev, A. V., Korataev, A. L., Kalinin, N. L. (1999). S-reaktivnyi belok v klinike [C-reactive protein in the clinic]. Klinicheskaya laboratornaya diagnostik, 6, 36–40.

Weinberg, G. A., Powel, K. P., Remington, J. S., Klein, J. O.; Sauder, W. B. (Ed.) (2001). Laboratory aids for diagnosis of neonatal sepsis. Infectious diseases of the fetus and newborn infant. Philadelphia, 1327–1344.

Fletcher, R. H., Fletcher, S. W., Wagner, E. H. (1992). Clinical epidemiology – the essentials. London: William Wilkins Baltimore, 223.

Schultz, C., Rott, C., Temming, P., Schlenke, P., Möller, J. C., Bucsky, P. (2002). Enhanced Interleukin-6 and Interleukin-8 Synthesis in Term and Preterm Infants. Pediatric Research, 51 (3), 317–322. doi: http://doi.org/10.1203/00006450-200203000-00009

Abdollahi, A., Morteza, A., Nayyeri, F. (2011). Procalcitonin, Interleukin-6 and High Sensitivity C Reactive Protein in the Early Prediction of Neonatal Sepsis, are they Correlated? Pediatric Research, 70, 426–426. doi: http://doi.org/10.1038/pr.2011.651

Vijayan, A. L., Vanimaya, Ravindran, S., Saikant, R., Lakshmi, S., Kartik, R., G, M. (2017). Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy. Journal of Intensive Care, 5 (1). doi: http://doi.org/10.1186/s40560-017-0246-8

Pontrelli, G., De Crescenzo, F., Buzzetti, R., Jenkner, A., Balduzzi, S., Calò Carducci, F. et. al. (2017). Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis. BMC Infectious Diseases, 17 (1). doi: http://doi.org/10.1186/s12879-017-2396-7

Zou, Q., Wen, W., Zhang, X. (2014). Presepsin as a novel sepsis biomarker. World Journal of Emergency Medicine, 5 (1), 16–19. doi: http://doi.org/10.5847/wjem.j.issn.1920-8642.2014.01.002

Wu, J., Hu, L., Zhang, G., Wu, F., He, T. (2015). Accuracy of Presepsin in Sepsis Diagnosis: A Systematic Review and Meta-Analysis. PLOS ONE, 10 (7), e0133057. doi: http://doi.org/10.1371/journal.pone.0133057

DOI: http://dx.doi.org/10.21303/2504-5679.2018.00728


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