IL-4 POLYMORPHISM IN PATIENTS WITH ACUTE BRUCELLOSIS IN THE REPUBLIC OF AZERBAIJAN

Elchin Mammad oglu Huseynov

Abstract


Currently, there are isolated data on the relationship between IL-4 polymorphism (C-589T) and susceptibility to brucellosis. Therefore, the purpose of the study was to determine the frequency of polymorphism of IL-4 (C-589T) in patients with acute brucellosis.

Materials and methods: the article presents the results of surveys of 120 patients with acute brucellosis. The control group consisted of 30 practically healthy persons. The diagnosis of brucellosis was based on complaints, anamnesis, epidemiological and clinical data, and the results of a specific study. The definition of the polymorphism of IL-4 (C-589T) was performed for all patients in the main and control group. A detailed description of patients with brucellosis is presented. Among the observed prevailed men and young people of working age.

Results: A mild degree was established in 74 (61.66 %) patients, while severe - only in 11 (9.17 %) patients. It was determined that the genotype CT (65.83 %) was significantly more common among patients with brucellosis than in the control group, where the frequency of this genotype was only 16.66 %. While the CC genotype was 3.2 times more common among healthy individuals than among patients in the main group (76.67 % versus 24.17 %), it was found that the CC genotype of the IL-4 gene was 13 times more common in patients for acute brucellosis with mild progress than with severe.

Conclusions: The genotype IL-4 (C-589T) SS is significantly associated with the mild course of brucellosis.


Keywords


acute brucellosis; cytokine; interleukin-4; polymorphism; genotype

Full Text:

PDF

References


Najafi, N., Davoudi, A., Hassantabar, S. R., Haddadi, R. (2018). Investigating the Epidemiologic, Laboratory, and Clinical Features of Brucellosis Patients Hospitalized in the North of Iran During 2009–2014. Archives of Clinical Infectious Diseases, 13 (2). doi: http://doi.org/10.5812/archcid.61012

Mugahi, S., Nashibi, R., Alavi, S. M., Gharkholu, S., Najafi, K. (2014). Epidemiological Features, Clinical Manifestation and Laboratory Findings of Patients With Brucellosis. Archives of Clinical Infectious Diseases, 9 (1). doi: http://doi.org/10.5812/archcid.17270

Pappas, G., Akritidis, N., Bosilkovski, M., Tsianos, E. (2005). Medical progress: brucellosis. New England Journal of Medicine, 352 (22), 2325–2336. doi: http://doi.org/10.1056/nejmra050570

Garcell, H. G., Garcia, E. G., Pueyo, P. V., Martín, I. R., Arias, A. V., Alfonso Serrano, R. N. (2016). Outbreaks of brucellosis related to the consumption of unpasteurized camel milk. Journal of Infection and Public Health, 9 (4), 523–527. doi: http://doi.org/10.1016/j.jiph.2015.12.006

Nourbakhsh, F., Borooni, S., Barangi, S., Tajbakhsh, E. (2017). Diagnosis of clinical and laboratory findings of brucellosis in Isfahan. International Archives of Health Sciences, 4 (2), 48. doi: http://doi.org/10.4103/iahs.iahs_1_17

Ahmad Reza, M., Samira, A., Amir Hossein, H., Behnam, S. et. al. (2017). Serum interferon-gamma and interleukin-4 in patients with brucellosis before and after treatment. Asian Pacific Journal of Tropical Disease, 7 (7), 396–400. doi: http://doi.org/10.12980/apjtd.7.2017d6-464

De Figueiredo, P., Ficht, T. A., Rice-Ficht, A., Rossetti, C. A., Adams, L. G. (2015). Pathogenesis and Immunobiology of Brucellosis. The American Journal of Pathology, 185 (6), 1505–1517. doi: http://doi.org/10.1016/j.ajpath.2015.03.003

Rodriguez-Zapata, M., Matias, M. J., Prieto, A., Jonde, M. A., Monserrat, J., Sanchez, L. et. al. (2010). Human Brucellosis Is Characterized by an Intense Th1 Profile Associated with a Defective Monocyte Function. Infection and Immunity, 78 (7), 3272–3279. doi: http://doi.org/10.1128/iai.01385-09

Inanir, A., Tural, S., Yigit, S., Kalkan, G., Pancar, G. S., Demir, H. D., Ates, O. (2013). Association of IL-4 gene VNTR variant with deep venous thrombosis in Behçet’s disease and its effect on ocular involvement. Molecular vision, 19, 675–683.

Micheal, S., Minhas, K., Ishaque, M., Ahmed, F., Ahmed, A. (2013). IL-4 Gene Polymorphisms and Their Association With Atopic Asthma and Allergic Rhinitis in Pakistani Patients. Journal of Investigational Allergology and Clinical Immunology, 23 (2), 107–111.

Trajkov, D., Mirkovska-Stojkovikj, J., Petlichkovski, A., Strezova, A., Efinska-Mladenovska, O., Sandevska, E. et. al. (2009). Association of cytokine gene polymorphisms with chronic obstructive pulmonary disease in Macedonians. Iranian Journal of Allergy, Asthma and Immunology, 8 (1), 31–42.

Gunal, O., Yigit, S., Yalcın, A. D., Celik, B., Barut, S., Demir, O. et. al. (2017). The IL4-VNTR P1 Allele, IL4-VNTR P2P2 Genotype, and IL4-VNTR_IL6-174CG P2P1-GG Genotype Are Associated with an Increased Risk of Brucellosis. Japanese Journal of Infectious Diseases, 70 (1), 61–64. doi: http://doi.org/10.7883/yoken.jjid.2015.550

Rasouli, M., Kiany, S. (2007). Association of interferon-gamma and interleukin-4 gene polymorphisms with susceptibility to brucellosis in Iranian patients. Cytokine, 38 (1), 49–53. doi: http://doi.org/10.1016/j.cyto.2007.05.003

Sanaei Dashti, A., Karimi, A., Elyasi, B., Shamshiri, A. R., Shoja, S. A., Shamshiri, M. (2017). Cytokine Profiles in Acute Brucellosis, Compared with Those in Other Febrile Illnesses. Archives of Clinical Infectious Diseases, 12 (4). doi: http://doi.org/10.5812/archcid.66077

Demirdag, K., Ozden, M., Kalkan, A., Godekmerdan, A., Sirri Kilic, S. (2003). Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers. FEMS Immunology & Medical Microbiology, 39 (2), 149–153. doi: http://doi.org/10.1016/s0928-8244(03)00207-4

Belozerov, E. S. (1985). Brucellez. Leningrad: Medicina, 184.

Rezazadeh, M., Hajilooi, M., Haidari, M., Rafiei, A., Ahmad Alavi, S., Keramat, F. (2006). Association of susceptibility to brucellosis and interleukin-4 promoter polymorphism. Scandinavian Journal of Infectious Diseases, 38 (11-12), 1045–1049. doi: http://doi.org/10.1080/00365540600786473

Budak, F., Göral, G., Heper, Y., Yılmaz, E., Aymak, F., Baştürk, B. et. al. (2007). IL-10 and IL-6 gene polymorphisms as potential host susceptibility factors in Brucellosis. Cytokine, 38 (1), 32–36. doi: http://doi.org/10.1016/j.cyto.2007.04.008

Eskandari-Nasab, E., Moghadampour, M., Asadi-Saghandi, A., Kharazi-nejad, E., Rezaeifar, A., Pourmasoumi, H. (2013). Levels of Interleukin-(IL)-12p40 are Markedly Increased in Brucellosis Among Patients with SpecificIL-12BGenotypes. Scandinavian Journal of Immunology, 78 (1), 85–91. doi: http://doi.org/10.1111/sji.12054

Sofian, M., Ramezani, A., Mousavi, A., Banifazl, M., Cherei, S., Cherei, A., Aghakhani, A. (2016). Interlukine-17 and TGF-β levels in patients with acute brucellosisbefore and after treatment. Turkish journal of medical sciences, 46, 1348–1352. doi: http://doi.org/10.3906/sag-1506-59




DOI: http://dx.doi.org/10.21303/2504-5679.2018.00800

Refbacks

  • There are currently no refbacks.




Copyright (c) 2018 Elchin Mammad oglu Huseynov

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

ISSN 2504-5679 (Online), ISSN 2504-5660 (Print)