Email this article THE FEATURES OF ARTERIAL THYMUSATNALBUPHINEACTION
Abstract
The article presents and analyzes the results of the pilot study, at which opioid nalbuphine was daily administered in white rats-males of reproductive age (1,5–3,5 – month) for six weeks and one week after discontinuation of therapy. The drug “nalbuphine” was injected intraperitoneally daily 1 per day over 42 days. The data were compared with a control group of intact animals. The study was conducted on 52 animals, which were divided into eight groups.
Morphometric study was performed using a system of visual analysis of histological preparations. Dynamics of changes in the external and internal diameters of medium caliber arteries thymus, media and lumen area, Vohenvorta ratio was studied.
The increase of the external diameter and reduction of the internal diameter of the medium caliber arteries, increase of the area of media, increase of the area of the lumen, increase of the Vohenvortaratio.The blood vessels are dilated, gaps filled elements of the blood vessels around the swelling, the process of vascular sclerosis.
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Davidovich, O. V., Kopcha, V. S., Masliy, K. O. (2011). Pharmacotherapy of pain. Rational pharmacotherapy, 4 (21), 66–68.
Unexplained illness and death among injecting-drug users-Glasgow, Scotland; Dublin, Ireland; and England, April-June 2000 (2000). Morbid. Mortal. Wkly Rep, 49, 489–492.
Deeva, T. V., Maslovsky, S. U. (1999). Effect of Levamisol on morphological changes in thymus, bone marrow and spleen of rats. Journal of Morphology, 5 (1), 37–38.
McCarthy, L., Wetzel, M., Sliker, J. K., Eisenstein, T. K., Rogers, T. J. (2001). Opioids, opioid receptors, and the immune response. Drug and Alcohol Dependence, 62 (2), 111–123. doi: 10.1016/s0376-8716(00)00181-2
Smith-Slatas, C. L. (2006). Clostridium septicum Infections in Children: A Case Report and Review of the Literature. Pediatrics, 117 (4), e796–e805. doi: 10.1542/peds.2005-1074
Díaz, F., Villena, A., Vidal, L., Moreno, M., García-Campos, J., de Vargas, I. P. (2010). Experimental Model of Ocular Hypertension in the Rat: Study of the Optic Nerve Capillaries and Action of Hypotensive Drugs. Investigative Opthalmology & Visual Science, 51 (2), 946. doi: 10.1167/iovs.09-3667
Cherkasov, E. V. (2012). The ultrastructure of thymic dendritic cells in experimental burn disease in rats and under the conditions of combined treatment hyperosmolar solutions. Bulletin morphology, 18 (1), 6–10.
Lee, A. V., Kashchenko, S. A., Zakharov, A. A. (2009). Features of thymus structure of experimental animals after imunofan administration.Ukrainian medical almanac, 12 (1), 33–34.
Nakahara, T., Uchi, H., Lesokhin, A. M., Avogadri, F., Rizzuto, G. A., Hirschhorn-Cymer-
man, D. et. al (2010). Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs. Blood, 115 (22), 4384–4392. doi: 10.1182/blood-2009-11-251231
Prakash, Gupta, V., Singh, S. M., Singh, M. P., Singh, G. (2007). Effect of Intrauterine Exposure of Murine Fetus to Cyclophosphamide on Development of Thymus. Immunopharmacology and Immunotoxicology, 29 (1), 17–30. doi:10.1080/08923970701277635
Gorlov, N. V., Kashchenko, S. A., Zakharov, A. A. (2009). Morphological features of thymusstructure of immaturerats after cyclophosphanum introduction. Ukrainian medical almanac, 12 (1), 23–24.
Zakharov, A. A. (2009). Morphological changes of thymus structure of immature rats after imunofan administration. Ukrainian medical almanac, 12 (1), 66–67.
Kashchenko, S. A. (2003). Features ultramykroskopyc structure thymus gland of administering a rat after cyclophosphamide. Ukrainian medical almanac, 6 (3), 66–69.
Kashchenko, S. A., Zakharov, A. A. (2008). Changes of thymus structure of mature white rats after cyclophosphanum application. Macedonian journal of medical sciences, 1, S36.
Lee, A. V., Zakharov, A. A., Kashchenko, S. A. (2008). Morphological changes of structure of thymus and features of indexes of peripheral blood of mature rats after introduction of cyclophosphan. Ukrainian medical almanac, 11 (1), 186–187.
Nakahara, T., Uchi, H., Lesokhin, A. M., Avogadri, F., Rizzuto, G. A., Hirschhorn-Cymerman, D. et. al (2010). Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs. Blood, 115 (22), 4384–4392. doi: 10.1182/blood-2009-11-251231
Diskovskyi, I. S. (2014). Features of the reparative process under influence of opioid in experiment. RECOOP 5 thTriNet Meeting Wroclaw, 60.
Mateschuk-Vatseba, L. R., Diskovskyy, S.(2014). Ultrastructural changes of rat skin during prolonged exposure to opioid. Bulletin of Ukrainian Medical Dental Academy «Actual problems of modern medicine.», 14 (4), 205–208.
Pidvalna, U. Y. (2014). Influence of opioid on the condition of the uvea in the course of the experiment. RECOOP 5th TriNet Meeting Wroclaw.Wroclaw, 53.
Onysko, R. M., Paltov, E. V., Fic, V. B., Vilhova, I. V., Kryvko, U. Y., Jakymiv, N. Y., Fitkalo, A. S. (2012). Pat. 76564 U Ukraine, IPC F 61 K 31/00 Method simulation of physical opioid dependence in rats. № u201207124; appl. 12.06.2012; publ. 01/10/2013. Bull. № 1.
Evropejs’ka konvencіja pro zahist hrebetnih tvarin, shho vikoristovujut’sja dlja doslіdnih ta іnshih naukovih cіlej (1986). Verhovna Rada Ukrai’ny. Available at: http://zakon4.rada.gov.ua/laws/show/994_137
Jevropejs’kyj Parlament ta Rada Jevropejs’kyh spivtovarystv (2004). Verhovna Rada Ukrai’ny. Availalbe at:http://zakon4.rada.gov.ua/laws/show/994_961
Pro zahyst tvaryn vid zhorstokogo povodzhennja (2006). Verhovna Rada Ukrai’ny. Available at: http://zakon3.rada.gov.ua/laws/show/3447-15
DOI: http://dx.doi.org/10.21303/2504-5679.2016.00091
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