COMPARISON OF THE DYNAMIC CHANGES OF AMINO ACID BLOOD PLASMA SPECTRUM IN PATIENTS WITH THE PRIMARY CEREBRAL ISCHEMIC STROKE DEPENDING ON THE POSTAPOPLECTIC SPASTICITY DEVELOPMENT IN THE RECOVERY PERIOD

  • Anzhelika Payenok Danylo Halytsky Lviv National Medical University, Ukraine
  • Maria Bilobryn Danylo Halytsky Lviv National Medical University, Ukraine
  • Iryna Mitelman Danylo Halytsky Lviv National Medical University, Ukraine
Keywords: primary cerebral ischemic stroke, excitatory and inhibitory neurotransmitters, most acute period, early recovery period, postapoplectic spasticity

Abstract

The aim of research was to reveal the dynamic changes of the level of excitatory and inhibitory neuroamino acids in patients with the primary cerebral ischemic stroke depending on postapoplectic spasticity presence at the end of the early recovery period.
For this aim was studied the concentration of excitatory and inhibitory neuroamino acids in the blood plasma in first 72 hours in 97 patients with the primary ischemic cerebral stroke depending on postapoplectic spasticity on the sixth month after ischemic event. The control group included 15 patients with diagnosed chronic cerebral ischemia.
In the result of research we revealed that the common sign for the two groups (with spasticity on the sixth month and without it) was the reliable rise of the level of excitatory amino acids comparing with the control. In patients without spasticity the heightened level of excitatory neurotransmitters in the most acute period of ischemic cerebral stroke was attended with the heightened level of inhibitory neuroamino acids. The distinctive feature of patients with postapoplectic spasticity was the decreased or stable level of transmitters of inhibitory action. During 6th moth after ischemic stroke was detected the rise of all studied neuroamino acids in patients with spasticity unlike to the ones without spasticity who were characterized only with the rise of taurine level and decrease of glycine and aspartate levels.
So, the received results allow assume the insufficient activation of the inhibitory neuroamino acids system in the most acute period of the ischemic stroke in certain category of patients that in future are inclined to the spasticity development after stroke.

Downloads

Download data is not yet available.

Author Biographies

Anzhelika Payenok, Danylo Halytsky Lviv National Medical University

Department of neuropathology and neurosurgery FPGE

Maria Bilobryn, Danylo Halytsky Lviv National Medical University

Department of neuropathology and neurosurgery FPGE

Iryna Mitelman, Danylo Halytsky Lviv National Medical University

Department of neuropathology and neurosurgery FPGE

References

Gnatejko, O., Sadova, O. (2009). Some aspects of early diagnosis of asthma in children. Child health, 5 (20), 34–38.

Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J. et. al (2013). International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. European Respiratory Journal, 43 (2), 343–373. doi: 10.1183/09031936.00202013

GINA-Report-2012 (E-resource). Available at: http://ginaasthma.org

Bush, A., Saglani, S. (2010). Management of severe asthma in children. The Lancet, 376 (9743), 814–825. doi: 10.1016/s0140-6736(10)61054-9

Lötvall, J., Akdis, C. A., Bacharier, L. B., Bjermer, L., Casale, T. B., Custovic, A. et. al (2011). Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome. Journal of Allergy and Clinical Immunology, 127 (2), 355–360. doi: 10.1016/j.jaci.2010.11.037

Hedlin, G., Bush, A., Lodrup Carlsen, K., Wennergren, G., De Benedictis, F. M., Melen, E. et. al (2010). Problematic severe asthma in children, not one problem but many: a GA2LEN initiative. European Respiratory Journal, 36 (1), 196–201. doi: 10.1183/09031936.00104809

Green, R. H., Pavord, I. (2012). Stability of inflammatory phenotypes in asthma. Thorax, 67 (8), 665–667. doi: 10.1136/thoraxjnl-2012-201657

Lang, A., Carlsen, K. H., Haaland, G., Devulapalli, C. S., Munthe-Kaas, M., Mowinckel, P., Carlsen, K. (2008). Severe asthma in childhood: assessed in 10year olds in a birth cohort study. Allergy, 63 (8), 1054–1060. doi: 10.1111/j.1398-9995.2008.01672.x

Bush, A., Hedlin, G., Carlsen, K.-H., de Benedictis, F., Lodrup-Carlsen, K., Wilson, N. (2008). Severe childhood asthma: a common international approach? The Lancet, 372 (9643), 1019–1021. doi: 10.1016/s0140-6736(08)61422-1

Simões, S. de M., Cunha, S. S. da, Barreto, M. L., Cruz, Á. A. (2010). Distribuição da gravidade da asma na infância. Jornal de Pediatria, 86 (5), 417–423. doi: 10.1590/s0021-75572010000500011

Franco, R., Nascimento, H. F., Cruz, A. A., Santos, A. C., Souza-Machado, C., Ponte, E. V. et. al (2009). The economic impact of severe asthma to low-income families. Allergy, 64 (3), 478–483. doi: 10.1111/j.1398-9995.2009.01981.x

Silvestri, M., Pistorio, A., Battistini, E., Rossi, G. A. (2010). IgE in childhood asthma: relevance of demographic characteristics and polysensitisation. Archives of Disease in Childhood, 95 (12), 979–984. doi: 10.1136/adc.2009.163667

Soyer, O. U., Akdis, M., Ring, J., Behrendt, H., Crameri, R., Lauener, R., Akdis, C. A. (2012). Mechanisms of peripheral tolerance to allergens. Allergy, 68 (2), 161–170. doi: 10.1111/all.12085

Lora-mladshego, G., Fishera, T., Adel’mana, D. (Eds.) (2000). Klinicheskaya immunologiya i alergologiya [Clinical Immunology and Allergology]. Moscow: Practice.

Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J. et. al (2013). International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. European Respiratory Journal, 43 (2), 343–373. doi: 10.1183/09031936.00202013

Ogorodova, L., Petrovskij, F., Korostovcev, D., Alikova, O. (2004). Severe asthma in children: results of a multicenter national study «NABAT». Allergology, 3, 3–9.

Barreto M.L., Cunha S. S., Alcantara-Neves N., Carvalho L. P., Cruz A. A., Stein R. T., et al. (2006). Risk factors and immunological pathways for asthma and other allergic diseases in children: background and methodology of a longitudinal study in a large urban center in Northeastern Brazil (Salvador-SCAALA study). BMC Pulmonary Medicine, 6 (1), 15. doi:10.1186/1471-2466-6-15

Nagakumar, P., Thomas, H. (2013). Management of severe asthma in children. Paediatrics and Child Health, 23 (7), 291–295. doi: 10.1016/j.paed.2013.05.010

Cruz, A. A., Bousquet, P. J. (2009). The unbearable cost of severe asthma in underprivileged populations. Allergy, 64 (3), 319–321. doi: 10.1111/j.1398-9995.2009.02026.x

Waserman, S., Nair, P., Snider, D. (2012). Local and systemic immunological parameters assjciated with remission of asthma symptoms in children. Allergy, asthma and clinical immunology, 8 (16), 1–14.

Kostromina, V. P., Rechkina, O. O., Mel`ny`k, K. O., Doroshenkova, A. S., Stry`zh, V. O., Yaroshhuk, L. B. (2013). Risk factors of bronchial asthma in children. Asthma and Allergies, 2, 21–23.

primary cerebral ischemic stroke; excitatory and inhibitory neurotransmitters; most acute period; early recovery period; postapoplectic spasticity

Skvorzova, V. I., Raevskiy, K. S., Kovalenko, A. V. (2006). Contents of neurotransmitter amino acids in cerebrospinal fluid of ischemic stroke patietn’s. Korsakov journal of neurology and psychiatry, 99 (2), 34–38.

Butter, Th., Meves, S., Schute, W. et. al (2008). Temporal profile of excitotoxic amino acids plasma concentrations following acute ischemic infarction. Cerebrovas. Dis., 8 (4), 79.

Dietrich, W. D., Globus, M. Y. T. (Eds.) (1992). The role of neurotransmitters in brain injury. Springer science + business media LLC, New York, 378. doi: 10.1007/978-1-4615-3452-5

Gusev, E. I., Skvorzova, V. I. (2002). Neurotransmission of glutamate and Ca2+ metabolism in normal condition and associated with cerebral ischemia. Uspehi fiziologicheskih nauk, 33 (4), 80–93.

Castillo, J., Davalos, A., Naveiro, J., Noya, M. (1996). Neuroexcitatory Amino Acids and Their Relation to Infarct Size and Neurological Deficit in Ischemic Stroke. Stroke, 27 (6), 1060–1065.

doi: 10.1161/01.str.27.6.1060

Chesselet, M. F., Delfs, J. M. (2011). Trends Neurosci., 19, 417–418.

Herring, B. E., Silm, K., Edwards, R. H., Nicoll, R. A. (2015). Is Aspartate an Excitatory Neurotransmitter? Journal of Neuroscience, 35 (28), 10168–10171. doi: 10.1523/jneurosci.0524-15.2015

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System (2011). doi: 10.17226/13146

Niciu, M. J., Kelmendi, B., Sanacora, G. (2012). Overview of glutamatergic neurotransmission in the nervous system. Pharmacology Biochemistry and Behavior, 100 (4), 656–664. doi: 10.1016/j.pbb.2011.08.008

Cocchiarella, A., Downev, I. A., Darling, R. C. (1967). Evaluation of the effect of diazepam on spasticity. Arch. Phys. Med. Rehabil., 48, 393–396.

Ben Best. Brain Neurotransmitters. Available at: http://www.benbest.com/science/anatmind/anatmd10.html#glutamate

López-Corcuera, B., Geerlings, A., Aragón, C. (2001). Glycine neurotransmitter transporters: an update. Molecular Membrane Biology, 18 (1), 13–20. doi: 10.1080/09687680010028762

Bowery, N. G., Smart, T. G. (2009). GABA and glycine as neurotransmitters: a brief history. British Journal of Pharmacology, 147 (S1), S109–S119. doi: 10.1038/sj.bjp.0706443

Davis, L. E., Pirio, S. (2015). Fundamentals of Neurologic Disease. doi: 10.1007/978-1-4939-2359-5

Rank, M. M., Li, X., Bennett, D. J., Gorassini, M. A. (2007). Role of Endogenous Release of Norepinephrine in Muscle Spasms After Chronic Spinal Cord Injury. Journal of Neurophysiology, 97 (5), 3166–3180. doi: 10.1152/jn.01168.2006

Voerman, G., Gregorič, M., Hermens, H. (2005). Neurophysiological methods for the assessment of spasticity: The Hoffmann reflex, the tendon reflex, and the stretch reflex. Disability and Rehabilitation, 27 (1-2), 33–68. doi: 10.1080/09638280400014600

Watkins, C., Leathley, M., Gregson, J., Moore, A., Smith, T., Sharma, A. (2002). Prevalence of spasticity post stroke. Clinical Rehabilitation, 16 (5), 515–522. doi: 10.1191/0269215502cr512oa

Sunnerhagen, K. S., Olver, J., Francisco, G. E. (2013). Assessing and treating functional impairment in poststroke spasticity. Neurology, 80 (3), S35–S44. doi: 10.1212/wnl.0b013e3182764aa2

Volker F. Wendisch, Alexsander Steinbuchel (2009). Amino Acid Biosynthesis – Pathways, regulation and Metabolic Engineering. Schmidt and Vockler GbR, Leipzig, Germany.

Wendisch, V. F. (Ed.) (2007). Amino Acid Biosynthesis ~ Pathways, Regulation and Metabolic Engineering. Microbiology Monographs. doi: 10.1007/978-3-540-48596-4

Donald, P., George, S., Scott, B. (Eds.) (2012). Basic neurochemistry. American society for neurochemistry, Elsevier, 1016.


👁 548
⬇ 332
Published
2016-06-10
How to Cite
Payenok, A., Bilobryn, M., & Mitelman, I. (2016). COMPARISON OF THE DYNAMIC CHANGES OF AMINO ACID BLOOD PLASMA SPECTRUM IN PATIENTS WITH THE PRIMARY CEREBRAL ISCHEMIC STROKE DEPENDING ON THE POSTAPOPLECTIC SPASTICITY DEVELOPMENT IN THE RECOVERY PERIOD. EUREKA: Health Sciences, (3), 17-23. https://doi.org/10.21303/2504-5679.2016.00095
Section
Medicine and Dentistry