Email this article ELECTRON MICROSCOPIC STUDYING OF RAT BONE CELLS UNDER MICROGRAVITY CONDITIONS
Abstract
In the experiments on rats (SLS-2) with the use of electron microscopy there was made the study of the osteoclasts population and the peculiarities of resorptive processes in a spongy bone of the epiphyses and the iliac crest.
The results of investigation permit to suppose that the processes of resorption of bone tissue become more intensive in zones of adaptive remodeling and destruction of the spongy bone under microgravity that is performed by several ways. One of mechanisms is the increasing of the functional activity of osteoclasts (appearance of "giant" osteoclasts). As a result it is the local demineralization and subsequent destruction of superficial areas of the bone matrix. The other mechanism is activation of osteocytic osteolysis was also investigated.
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References
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DOI: http://dx.doi.org/10.21303/2504-5695.2016.00048
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