Alevtyna Kononenko, Vera Kravchenko


The present work studied the effect of aqueous extract from Feijoa leaves on thyroid function of rats with experimental hypothyroidism. Healthy albino rats weighing between 120 gand 150 gwere used. The animals were randomly allotted into four groups, each containing eight rats respectively. Three of the groups (II, III and IV), induced with hypothyroidism, were treated by 0.05 % solution of thiamazole with drinking water for 30 days. Control (vehicle) rats were given normal saline. After 13 days hypothyroid groups (III and IV) of rats were treated with aqueous extract from Feijoa leaves at a dose 1.0 ml/100 g of body weight and with Iodomarin 200 (reference drug) at a dose 12 µg/kg daily orally for 21 days. Results obtained from the study showed that the introduction of thiamazole leads to functional changes in the thyroid gland in rats, accompanied by decreasing sings of rectal temperature and level of thyroid hormones. It was found, that treatment with AEFL normalizes serum thyroid hormone levels, increases rectal temperature and reduces the thyroid mass. The investigated extract can be attributed to the regulators of the thyroid hypofunction and is promising for further study of its effectiveness as a thyroid-stimulating agent.


Feijoa leaves; aqueous extract; hypothyroidism; thiamazole; thyroid hormones

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Kravchenko, V. І., Postol, S. V. (2011). The dynamics of morbidity in pathology of thyroid gland in Ukraine. International Endocrinological Journal, 3 (35), 26–31.

Bajaj, J. K., Salwan, P., Salwan, S. (2016). Various possible toxicants involved in thyroid dysfunction: A Review. Journal of Clinical and Diagnostic Research, 10 (1), FE01-FE03. doi: http://doi.org/10.7860/jcdr/2016/15195.7092

Mangge, H., Becker, K., Fuchs, D., Gostner, J. M. (2014). Antioxidants, inflammation and cardiovascular disease. World Journal of Cardiology, 6 (6), 462–477. doi: http://doi.org/10.4330/wjc.v6.i6.462

Javed, Z., Sathyapalan, T. (2015). Levothyroxine treatment of mild subclinical hypothyroidism: a review of potential risks and benefits. Therapeutic Advances in Endocrinology and Metabolism, 7 (1), 12–23. doi: http://doi.org/10.1177/2042018815616543

Volkov, V. P. (2014). A new approach to the evaluation of the morphofunctional state of the endocrine glands. Universum: Medicine and pharmacology, 9 (10). Available at: http://7universum.com/en/med/archive/item/1589

Vladymyrova, І. N. (2014). Standardization of Approaches to the Purposeful Search of Herbal Medicines for the Treatment of Thyroid Diseases. Kharkiv, 44.

Vladymyrova, І. N., Georgiyants, V. А. (2010). Analytical review of modern thyrotropic drugs. Pharmaceutical bulletin, 4, 90–93.

Lobanov, K. А., Kоrsun, V. F., Korsun, Е. V. (2019). Phytotherapy of hypothyroidism in the elderly. Available at: http://fito-news.ru/terapii/fitoterapiya/9035-fitoterapiya-gipotireoza-v-pozhilom-vozraste.html Last accessed: 13.04.2016

Kiselyova, I. A., Tyoplaya, E. V., Kaminskiy, A. V. (2012). Application of the herbal preparation "Alba" in the treatment of patients with pathology of the thyroid gland. Мedical case, 8, 108–119.

Kononenko, A. G., Kravchenko, V. M. (2016). Study of the influence of aqueous extract and tinctures of feijoa leaves on the synthetic thyroid gland function in rats. Bulletin of problems in biology and medicine, 2 (130), 151–154.

Glants, S. (1999). Mediko-biologicheskay statistica. Мoscow: Practika, 459.

Karpenko, N. O., Kravchenko, V. M., Orlova, V. O., Shcherbak, O. A., Korenieva, Y. M., Kononenko, A. H. (2016). Pat. 109608 UA. A modeling technique of experimental hypothyroidism in laboratory animals. MPK: A61K 31/00, G09B 23/28, A61P 5/14, A61K 9/08. No. u 2016 02673; declareted: 17.03.2016; published: 25.08.2016, Bul. No. 16.

Ahmetov, А. S., Doskina, Е. V. (2010). Akromegalia i gigantism, Мoscow: Geotar-Media, 21.

Keles, H., Ince, S., Küçükkurt, I., Tatli, I. I., Akkol, E. K., Kahraman, C., & Demirel, H. H. (2011). The effects ofFeijoa sellowianafruits on the antioxidant defense system, lipid peroxidation, and tissue morphology in rats. Pharmaceutical Biology, 50 (3), 318–325. doi: http://doi.org/10.3109/13880209.2011.608074

DOI: http://dx.doi.org/10.21303/2504-5695.2019.00889


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