Vira Tseluyko, Larysa Yakovleva, Fedia ben Salem


Our aim was to study the predictive value of NT proBNP regarding the risk of AF and clinical features in acute phase of ST-segment elevation MI (STEMI).

Methods. We examined 56 patients with STEMI and AF who did undergo the primary PCI. 35 (62.5 %) of patients had the new-onset AF (group 1), 21 (37.5 %) had pre-existing AF (group 2). Control group consisted of 60 patients with STEMI without AF (group 3).

Results. Group 3 patients were more likely to be smokers than patients in group 2. They had lower admission heart rate and glycemia, lower NT proBNP, higher hemoglobin and ejection fraction. Patients in group 1 were more likely to have anterior MI, left anterior descending artery as an infarction-related artery (IRA) and adverse cardiac events (MACEs). Patients in group 2 had higher left atrium end-systolic diameter and were more likely to have three-vessel injury. NT proBNP correlated positively with age, admission glycemia, mean PA pressure and negatively – with GFR.

ROC analysis had shown the cut-off point of NT proBNP level for prediction of AF was >1050 pg/ml. Cut-off point for prediction of the risk of MACE in STEMI complicated with AF was >2189 pg/ml.

Discussion. It was shown that NT proBNP is higher in STEMI patients who have AF. Increased NT proBNP is associated with the risk of adverse events in acute STEMI phase. NT proBNP level can be utilized as AF predictor in STEMI patients and as predictor of MACEs in patients with STEMI and AF.


myocardial infarction; primary percutaneous intervention; NT proBNP; prognosis; atrial fibrillation; pre-existing; new-onset; MACEs; complications; predictors

Full Text:



García-García, C., Ribas, N., Recasens, L. L., Meroño, O., Subirana, I., Fernández, A. et. al. (2017). In-hospital prognosis and long-term mortality of STEMI in a reperfusion network. “Head to head” analisys: invasive reperfusion vs optimal medical therapy. BMC Cardiovascular Disorders, 17 (1). doi:

Hudzik, B., Korzonek-Szlacheta, I., Szkodziński, J., Gierlotka, M., Lekston, A., Zubelewicz-Szkodzińska, B., Gąsior, M. (2017). Prognostic impact of multimorbidity in patients with type 2 diabetes and ST-elevation myocardial infarction. Oncotarget, 8 (61). doi:

Batra, G., Svennblad, B., Held, C., Jernberg, T., Johanson, P., Wallentin, L., Oldgren, J. (2016). All types of atrial fibrillation in the setting of myocardial infarction are associated with impaired outcome. Heart, 102 (12), 926–933. doi:

Opincariu, D., Chițu, I. M. (2018). Atrial Fibrillation and Acute Myocardial Infarction – An Inflammation-Mediated Association. Journal Of Cardiovascular Emergencies, 4 (3), 123–132. doi:

Reinstadler, S. J., Stiermaier, T., Eitel, C., Fuernau, G., Saad, M., Pöss, J. et. al. (2018). Impact of Atrial Fibrillation During ST-Segment–Elevation Myocardial Infarction on Infarct Characteristics and Prognosis. Circulation: Cardiovascular Imaging, 11 (2). doi:

Thygesen, K., Mair, J., Mueller, C., Huber, K., Weber, M., Plebani, M. et. al. (2011). Recommendations for the use of natriuretic peptides in acute cardiac care: a position statement from the Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care. European heart journal, 33 (16), 2001–2006. doi:

Ibanez, B., James, S., Agewall, S. Antunes, M. J., Bucciarelli-Ducci, C., Bueno, H. et. al. (2018). 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). European Heart Journal, 39 (2), 119–177. doi:

Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B. et. al. (2016). 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. European Journal of Cardio-Thoracic Surgery, 50 (5), e1–e88. doi:

Carvalho, L. S. F., Bogniotti, L. A. C., de Almeida, O. L. R., e Silva, J. C. Q., Nadruz, W., Coelho, O. R., Sposito, A. C. (2018). Change of BNP between admission and discharge after ST-elevation myocardial infarction (Killip I) improves risk prediction of heart failure, death, and recurrent myocardial infarction compared to single isolated measurement in addition to the GRACE score. European Heart Journal: Acute Cardiovascular Care, 8 (7), 643–651. doi:

Keskin, K., Güzelsoy, D. (2019). The relationship between myocardial viability and plasma NT-proBNP levels. Journal of Human Rhythm, 5 (3), 246–255.

Raut, S., Saurav, C., Mohapatra, C., Owaisi, N., Khan, A. A. (2017). The Role of N Terminal Pro-BNP in Assessing Severity of Coronary Artery Disease: A Prospective Study. International Journal of Cardiology and Heart Health, 1 (3), 43–49. doi:



  • There are currently no refbacks.

Copyright (c) 2019 Vira Tseluyko, Larysa Yakovleva, Fedia ben Salem

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

ISSN 2585-6634 (Online), ISSN 2585-6626 (Print)