TOXICOLOGICAL ASSESSMENT OF COMBINED FUNGICIDES PROPOSED FOR APPLICATION ON CEREAL SPIKED CROPS IN UKRAINE

Mykola Kondratiuk, Anna Blagaia

Abstract


Toxicological assessment of combined fungicides proposed for application on cereal spiked crops in Ukraine was performed according approved State Sanitary Norms and Rules. Statistics, bibliographical methods were used in the study. The classes of hazard were established after evaluation of toxicometry parameters, which included assessment of acute oral toxicity, acute dermal toxicity, acute inhalation toxicity, irritation potential to eyes (mucous membranes) and skin, and sensitizing properties. Integral hazard class of the studied formulations was established. Formulations No.1, 2, 3, 5 and 7 can be pertained to integral hazard class 2 by acute inhalation toxicity as limiting criterion of hazard (formulation No.1 also has additional point of concern – its irritation of the skin and eyes). Formulation No.4, 6 and 8 were classified as integral hazard class 3 by the same limiting criterion of hazard, but the danger of formulation No.4 possibility to cause sensitization and irritation of the eyes was taken into account. Recommendations for the studied combined fungicides application in agricultural sector of Ukraine were given. Maximum daily time of contact with formulations for workers engaged in its application on cereal spiked crops was suggested. 4 hours per day were approved for formulations No.1,2,3,5 and 7, and 6 hours per day for No. 6 and 8, respectively

Keywords


combined fungicides; acute oral; dermal; inhalation toxicity; irritation potential; and sensitization

Full Text:

PDF

References


Metodycheskye ukazanyia po hyhyenycheskoi otsenke novykh pestytsydov Methodical guidelines on hygienic assessment of the new pesticides (1987–1988). 4263-87: Approv. 13.03.87. MZ SSSR, 212.

Azoxystrobin. International union of pure and applied. Available at: http://sitem.herts.ac.uk/aeru/iupac/Reports/54.htm

Benzovindiflupyr. ChemSpider. Available at: http://www.chemspider.com/Chemical-Structure.28945614.html

Benzovindiflupyr (2015). Minnesota Department of Agriculture. Available at: http://www.mda.state.mn.us/chemicals/pesticides/regs/~/media/Files/chemicals/reviews/nairbenzovindiflupyr.pdf

Cyproconazole. International union of pure and applied. Available at: http://sitem.herts.ac.uk/aeru/iupac/Reports/198.htm

Epoxiconazole. International union of pure and applied. Available at: http://sitem.herts.ac.uk/aeru/iupac/Reports/267.htm

Fludioxonil. International union of pure and applied. Available at: http://sitem.herts.ac.uk/aeru/iupac/Reports/330.htm

Kresoxim-methyl. International union of pure and applied. Available at: http://sitem.herts.ac.uk/aeru/iupac/Reports/414.htm

Metalaxyl-M. International union of pure and applied. Available at: http://sitem.herts.ac.uk/aeru/iupac/Reports/445.htm

Prochloraz. International union of pure and applied. Available at: http://sitem.herts.ac.uk/aeru/iupac/Reports/536.htm

Propiconazole. International union of pure and applied. Available at: http://sitem.herts.ac.uk/aeru/iupac/Reports/551.htm

Tebuconazole. International union of pure and applied. Available at: http://sitem.herts.ac.uk/aeru/iupac/Reports/610.htm

Hihiyenichna klasyfikatsiya pestytsydiv za stupenem nebezpechnosti [Hygienic classification of pesticides according to the degree of danger] (1998). DSanPiN 8.8.1.002-98. Kyiv: Ministry of Health of Ukraine.




DOI: http://dx.doi.org/10.21303/2585-663.2017.00442

Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 Mykola Kondratiuk, Anna Blagaia

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

ISSN 2585-6634 (Online), ISSN 2585-6626 (Print)