RESEARCH OF ANTIMICROBIAL ACTIVITY OF ANTHELMINTHIC MIXTURE FOR NEMATODOSIS TREATMENT

Kateryna Semchenko, Kateryna Romas

Abstract


Parasitic infections are one of the most acute problems of the modern society as this group of diseases is met in all countries of the world. According to the World Health Organization around 1.2 billion people are infected with diverse parasitic infections each year. Helminthiases of digestive system, primarily nematodosis, constitute a group of special risk, since a particularly sensitive audience for them are children of younger and middle age.

Phytotherapy, which is based on the centuries-old experience of folk medicine, promises to be a solution to this problem, enabling to create effective complex medicines for nematodosis prevention and treatment. Thus, the herbal mixture was prepared on the basis of the offered composition of medicinal plant raw material.

The research of antimicrobial activity of the studied herbal mixture was conducted in vitro by the method of diffusion into agar at the Biotechnology Department of the National Pharmaceutical University under the direction of Doctor of Pharmaceutical Sciences, prof. Strelets O.P.

The obtained results of the carried out research of the antimicrobial properties of the herbal mixture samples allowed examining the level of antimicrobial activity.

The further research of the investigated herbal mixture and the offered phytocomposition is promising for creation of new effective medicines with the complex action including anthelminthic (specific to nematodes), antiparasitic, anti-inflammatory, antibacterial, antiseptic, hepatoprotective, nephroprotective, laxative, antiallergic, antispasmodic, analgesic, sedative activities

Keywords


nematodosis; helminthiases; medicines of natural origin; medicinal plant raw material; antimicrobial activity; parasitology; digestive system; phytotherapy; pharmacotherapy

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References


Bodnya, E. I. (2016). Vormil – a comprehensive solution to the problem of helminthiases and their consequences. News Medicine and Pharmacy, 5 (574), 8–10.

All about helminthiases. Herbalist. Available at: http://www.herbalist.ru/articles-vsjo-pro-glisty.html

Samura, B. A., Babak, O. Ya., Kolesnik, Yu. M. et. al. (2010). Pharmacotherapy. Kharkiv: Golden pages, 240.

Shadrin, O. G., Kovalchuk, A. A., Dyukareva, S. V., Polkovnichenko, L. M. (2015). Condition of gastrointestinal tract and ways of its correction by helminthiases at children. Sovremennaya pediatriya, 72, 88–91.

Ershova, I. B., Osychnyuk, L. M., Mochalova, G. O. (2013). Helminthiases in children. Perinatologiia i pediatriia, 2 (54), 125–131.

Minedian, G. Z. (Ed.) (2003). Collection of folk medicines and non-traditional methods of treatment. Moscow: Address-Press.

Samura, B. A., Chernyh, V. P., Bannyy, I. P. et. al. (2003). Phytotherapy in the clinic of internal diseases. Kharkiv: NUPh PH: Golden Pages, 416.

Tolochko, K. V., Vyshnevska, L. I. (2016). Basic approaches to pharmacotherapy of helminthiases and prospects of phytomedicines development for their treatment. Clinical Pharmacy, 20 (4), 4–10.

Tolochko, K. V., Vyshnevska, L. I. (2017). Scientific justification of anthelmintic medicines based on medicinal plant material. International Journal of Green Pharmacy, 11 (3), 154–159. doi: 10.22377/ijgp.v11i03.1119

State Pharmacopoeia of Ukraine. Vol. 1. (2015). Kharkiv: State Enterprise "Ukrainian Scientific Pharmacopoeial Center for Drug Quality", 1128.

Volyanskiy, Yu. L., Gritsenko, I. S., Shirobokov, V. P. et. al. (2004). Study of specific activity of antimicrobial drugs. Kyiv, 38.

Akhmetova, S. B., Koteneva, E. N., Kabduova, A. K. et. al. (2013). Epidemiology of ascariasis and influence of ascaride invasion on microflora of the thick intestine. Epidemiological studies in clinical medicine: achievements and prospects. Kharkiv: Digital printing-house, 1, 10–12.




DOI: http://dx.doi.org/10.21303/2585-663.2017.00456

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ISSN 2585-6634 (Online), ISSN 2585-6626 (Print)