SOME MARKERS OF SYSTEMIC INFLAMMATORY RESPONSE AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH NEUROLOGIC MANIFESTATIONS OF LUMBAR OSTEOCHONDROSIS

Shadid Fadi, Igor Krychun

Abstract


It has been established in numerous experimental and clinical studies that disc protrusion leads to a number of immunobiochemical processes and the inflammatory response of the body. It leads to a question: Aren’t the processes of herniation accompanied with endothelial dysfunction which can develop in connection with the chronic inflammatory process? The following research goal is set to address these issues: to study blood plasma for the content of some chronic inflammation markers and endothelial damage such as fibronectin, tumor necrosis factor (TNF-α) and soluble fms-like tyrosine kinase-1 (sFlt-1) in combination with the investigation of the functional state of the endothelium using Celermayer’s test in males under the age of 45 without signs of obesity and somatic or vascular pathology with various neurologic manifestations of lumbar osteochondrosis.

85 male patients have been examined for neurologic manifestations of spinal osteochondrosis at the age from 19 to 45. The examined patients included 45 individuals with radiculopathy verified by neuroimaging and 40 individuals with reflex manifestations of lumbar osteochondrosis.

It has been shown that the examined patients of young age with exacerbation of discogenic radiculopathy accompanied with a prolonged pain syndrome experience an increase of fibronectin and tumor necrosis factor-alpha in plasma against the background of a decrease in the concentration of soluble fms-like tyrosine kinase-1 that are markers of inflammation and endothelial damage.

The obtained data imply that patients with neurologic manifestations of osteochondrosis need active preventive measures of cardiovascular diseases with the mandatory inclusion of endothelial-tropic therapy

Keywords


Radiculopathy; lumbalgia; lumbar ischialgia; Celermayer’s test; endothelium-dependent vasodilation; fibronectin; sFlt-1; TNF-α; endothelial dysfunction; systemic inflammatory response

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DOI: http://dx.doi.org/10.21303/2585-663.2017.00461

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Copyright (c) 2017 Shadid Fadi, Igor Krychun, Igor Krychun

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ISSN 2585-6634 (Online), ISSN 2585-6626 (Print)