EVALUATION OF THE MAIN DATA OF INFLAMMATORY RESPONSE TO THE BASE THERAPY OF THE JUVENILE IDIOPATHIC ARTHRITIS

Yulia Vyzhga

Abstract


The activity of the juvenile idiopathic arthritis evaluates the speed of the process progression, intense of its clinical manifestation, effect of the carried treatment.

The aim of our study was to estimate changes of the inflammatory response signs as well as content of NF-kB due to basic therapy of the JIA.

Materials and methods. At our study, we had checked 68 children with JIA, who passed their treatment at Vinnytsya regional children’s hospital within the period from 2011 to 2014 years.

Results. At the patients we studied currency of the JIA was characterized with articular variant of the disease, mainly in monoarthritis type. Laboratory activity of the inflammatory response characterized with increased content of the C-reactive protein (71.2±3.7 %), inflammatory cytokines – ІL-1β (54.8±4.1 %) and ІL-6 (56.2±2.4 %), as well high quantity of the nuclear factor-kB (70.5±3.1 %). Currency of the JIA in children characterized with high increasing of the inflammatory response signs especially C-reactive protein (6.55(4.2;9.8)), ІL-1β (7.3(3.5;11.9)), ІL-6 (6.8(4.5;10.6)) and NF-kB (6.76 (4.8; 9.1)), that are in correlative connections with clinical signs (number of the injured and swelled joints, evaluation of the general condition of the child according to doctors and own response) of the disease activity (rxy = +0.34 up to 0.62, p< 0.01).

Conclusion. During the managing of the basic therapy in children with JIA we estimated decreasing of the IL-1β content in patients at the background of methotrexate administration (38.7±3.7 %), at the second group with use of sulfasalazine (28.5±3.5 %) and the third with leflunomide prescription (29.1±5.1 %), but significant decreasing of the ІL-6 content, that is one of the main inflammatory mediators and as well NF-kB was found just in group of the patients with methotrexate administration (on 36.3±3.8 % and 32.4±2.4 % for NF-kB).


Keywords


juvenile idiopathic arthritis; children; inflammatory markers; treatment; NF-kB; cytokines

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DOI: http://dx.doi.org/10.21303/2585-663.2018.00762

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ISSN 2585-6634 (Online), ISSN 2585-6626 (Print)