PROGESTERONE INSUFFICIENCY AS A PREDICTOR OF FUTURE REPRODUCTIVE LOSSES

Ludmyla Semeniuk

Abstract


The article presents new data on the significance of vitamin D deficiency in the formation of endometrial structure disorders in women with luteal phase defect and unrupted follicle syndrome. Disorders of the menstrual cycle caused by a progesterone deficiency from the position of influence on the onset and progression of pregnancy are considered.

Fertility of women, especially with endocrine imbalances, deserves special attention, since the frequency of early pregnancy loss in them is about 67 %.

Aim: study of the effects of vitamin D deficiency and progesterone deficiency in the luteinized unruptured follicle syndrome (Geis-Genes) and the luteal phase defect on the reproductive potential of women.

Materials and methods: a hormonal study, determination of vitamin D levels, a sonographic study conducted on days 5–7 and 21–24 of the menstrual cycle in the periconceptional supplementation program of 45 women with luteal phase deficiency (LPD) and luteinized unruptured follicle syndrome (LUF).

Results: The relationship between the content of vitamin D and the hormonal levels of the reproductive system of women with LPD and LUF is traced. The role of reducing vitamin D levels in the formation of hormonal imbalances in women of reproductive age has been established.

Conclusions:

– progesterone deficiency entails changes in various regulatory substances of the reproductive system, and therefore the periconceptional supplementation must be individual.

– The introduction of the definition of vitamin D in the periconceptional supplementation plan and its correction are justified and necessary to improve the structure of the endometrium and its secretory transformation in women with progesterone imbalance.


Keywords


reproductive function of women; hormonal imbalance; vitamin D

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References


Solov'eva, A. V., Raevskaya, O. A., Ipastova, I. D. (2018). Narusheniya menstrual'nogo cikla: pochemu ih nuzhno korrigirovat'? Status Praesens, 1, 52–57.

Rykova, O. V. (2016). Insufficient luteal phase: laboratory diagnostic aspects. Opinion of Practice Committee of the American Society for Reproductive Medicine. Reproductive Endocrinology, 1 (27), 106–110. doi: https://doi.org/10.18370/2309-4117.2016.27.106-110

UK Medical Eligibility Criteria for Contraceptive Use (2016). Available at: https://www.fsrh.org/documents/ukmec-2016/fsrh-ukmec-full-book-2017.pdf

Abdulaev, R. Ya., Dolenko, O. V., Shcherbakov, A. Yu., Tamm, T. I., Senchuk, A. Ya. (2010). Etiopathological aspects and ultrasound diagnosis of lutein phase insufficiency and syndrome of non-ovulated follicle luteinization. International Medical Journal, 16 (4), 78–81.

Larina, O. V. (2017). Influence of vitamin D deficiency on reproductive health of women. Clinical Endocrinology and Endocrine Surgery, 3 (59), 28–34. doi: https://doi.org/10.24026/1818-1384.3(59).2017.110889

Holick, M. F., Binkley, N. C., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P. et. al. (2011). Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology & Metabolism, 96 (7), 1911–1930. doi: https://doi.org/10.1210/jc.2011-0385

Stocco, C., Telleria, C., Gibori, G. (2007). The Molecular Control of Corpus Luteum Formation, Function, and Regression. Endocrine Reviews, 28 (1), 117–149. doi: https://doi.org/10.1210/er.2006-0022

Kelekci, S., Kaya, E., Alan, M., Alan, Y., Bilge, U., Mollamahmutoglu, L. (2005). Comparison of transvaginal sonography, saline infusion sonography, and office hysteroscopy in reproductive-aged women with or without abnormal uterine bleeding. Fertility and Sterility, 84 (3), 682–686. doi: https://doi.org/10.1016/j.fertnstert.2005.03.036

Current clinical irrelevance of luteal phase deficiency: a committee opinion (2015). Fertility and Sterility, 103 (4), e27–e32. doi: https://doi.org/10.1016/j.fertnstert.2014.12.128

The clinical relevance of luteal phase deficiency: a committee opinion (2012). Fertility and Sterility, 98 (5), 1112–1117. doi: https://doi.org/10.1016/j.fertnstert.2014.12.128

Harvey, N. C., Holroyd, C., Ntani, G., Javaid, K., Cooper, P., Moon, R. et. al. (2014). Vitamin D supplementation in pregnancy: a systematic review. Health Technology Assessment, 18 (45). doi: https://doi.org/10.3310/hta18450




DOI: http://dx.doi.org/10.21303/2585-663.2018.00773

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ISSN 2585-6634 (Online), ISSN 2585-6626 (Print)